CAMKK2 (NM_172226) Human Untagged Clone

CAT#: SC110186

CAMKK2 (untagged)-Human calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant 7

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CAMKK2
• Synonyms: CAMKK; CAMKKB
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_172226 edited
  ATGTCATCATGTGTCTCTAGCCAGCCCAGCAGCAACCGGGCCGCCCCCCAGGATGAGCTG
  GGGGGCAGGGGCAGCAGCAGCAGCGAAAGCCAGAAGCCCTGTGAGGCCCTGCGGGGCCTC
  TCATCCTTGAGCATCCACCTGGGCATGGAGTCCTTCATTGTGGTCACCGAGTGTGAGCCG
  GGCTGTGCTGTGGACCTCGGCTTGGCGCGGGACCGGCCCCTGGAGGCCGATGGCCAAGAG
  GTCCCCCTTGACACCTCCGGGTCCCAGGCCCGGCCCCACCTCTCCGGTCGCAAGCTGTCT
  CTGCAAGAGCGGTCCCAGGGTGGGCTGGCAGCCGGTGGCAGCCTGGACATGAACGGACGC
  TGCATCTGCCCGTCCCTGCCCTACTCACCCGTCAGCTCCCCGCAGTCCTCGCCTCGGCTG
  CCCCGGCGGCCGACAGTGGAGTCTCACCACGTCTCCATCACGGGTATGCAGGACTGTGTG
  CAGCTGAATCAGTATACCCTGAAGGATGAAATTGGAAAGGGCTCCTATGGTGTCGTCAAG
  TTGGCCTACAATGAAAATGACAATACCTACTATGCAATGAAGGTGCTGTCCAAAAAGAAG
  CTGATCCGGCAGGCCGGCTTTCCACGTCGCCCTCCACCCCGAGGCACCCGGCCAGCTCCT
  GGAGGCTGCATCCAGCCCAGGGGCCCCATTGAGCAGGTGTACCAGGAAATTGCCATCCTC
  AAGAAGCTGGACCACCCCAATGTGGTGAAGCTGGTGGAGGTCCTGGATGACCCCAATGAG
  GACCATCTGTACATGGTGTTCGAACTGGTCAACCAAGGGCCCGTGATGGAAGTGCCCACC
  CTCAAACCACTCTCTGAAGACCAGGCCCGTTTCTACTTCCAGGATCTGATCAAAGGCATC
  GAGTACTTACACTACCAGAAGATCATCCACCGTGACATCAAACCTTCCAACCTCCTGGTC
  GGAGAAGATGGGCACATCAAGATCGCTGACTTTGGTGTGAGCAATGAATTCAAGGGCAGT
  GACGCGCTCCTCTCCAACACCGTGGGCACGCCCGCCTTCATGGCACCCGAGTCGCTCTCT
  GAGACCCGCAAGATCTTCTCTGGGAAGGCCTTGGATGTTTGGGCCATGGGTGTGACACTA
  TACTGCTTTGTCTTTGGCCAGTGCCCATTCATGGACGAGCGGATCATGTGTTTACACAGT
  AAGATCAAGAGTCAGGCCCTGGAATTTCCAGACCAGCCCGACATAGCTGAGGACTTGAAG
  GACCTGATCACCCGTATGCTGGACAAGAACCCCGAGTCGAGGATCGTGGTGCCGGAAATC
  AAGCTGCACCCCTGGGTCACGAGGCATGGGGCGGAGCCGTTGCCGTCGGAGGATGAGAAC
  TGCACGCTGGTCGAAGTGACTGAAGAGGAGGTCGAGAACTCAGTCAAACACATTCCCAGC
  TTGGCAACCGTGATCCTGGTGAAGACCATGATACGTAAACGCTCCTTTGGGAACCCATTC
  GAGGGCAGCCGGCGGGAGGAACGCTCACTGTCAGCGCCTGGAAACTTGCTCACCAAAAAA
  CCAACCAGGGAATGTGAGTCCCTGTCTGAGCTCAAGGAAGCAAGGCAGCGAAGACAACCT
  CCAGGGCACCGACCCGCCCCCCGTGGGGGAGGAGGAAGTGCTCTTGTGAGAGGCAGTCCC
  TGCGTGGAAAGTTGCTGGGCCCCCGCCCCCGGCTCCCCCGCACGCATGCATCCACTGCGG
  CCGGAGGAGGCCATGGAGCCCGAGTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_172226 unedited
  ACTCGGATTTGTAACCGACTTATATAGGCGGCCGCGCAATTCGCACGAGGGCCGAGCCGA
  GCTGGGGGCGCAGAGCGCGGGAGGCGGCGGCGGCGCGGAGCCCAGGTGGCTCCGCTGCCG
  GATGGGAGTGCCCCAGTGTGCTGGATGAAGCTGGCGCATGCACCATGTCATCATGTGTCT
  CTAGCCAGCCCAGCAGCAACCGGGCCGCCCTTTTGTATGAGCTGGGGGGCAGGGGCAGCA
  GCAGCAGCGAAAGCCAGAAGCCCTGTGAGGCCCTGCGGGGCCTCTCATCCTTGAGCATCC
  ACCTGGGCATGGAGTCCTTCATTGTGGTCACCGAGTGTGAGCCGGGCTGTGCTGTGGACC
  TCGGCTTGGCGCGGGACCGGCCCCTGGAGGCCGATGGCCAAGAGGTCCCCCTTGACACCT
  CCGGGTCCCAGGCCCGGCCCCACCTCTCCGGTCGCAAGCTGTCTCTGCAAGAGCGGTCCC
  AGGGTGGGCTGGCAGCCGGTGGCAGCCTGGACATGAACGGACGCTGCATCTGCCCGTCCC
  TGCCCTACTCACCCGTCAGCTCCCCGCAGTCCTCGCCTCGGCTGCCCCGGCGGCCGACAG
  TGGAGTCTCACCACGTCTCCATCACGGGTATGCAGGACTGTGTGCAGCTGAATCAGTATA
  CCCTGGAAGATGAAATTGGAAAGGGCTCCTATGGTGTCGTCAAGTTGGCCTACAATGAAN
  ATGAACATACCTACTATGCAATGAAAGTGCTGTCCAAAAAGAAGCTGATCCGGCAGGNNC
  CGCTTCCACGTCGCCCTCCACCCCGAGGCACCCGGCCAGCTNCTGGNAGCTGCATCCAGC
  CCNAGGGGCCCCATTGAGCAGGTGTACCAGGAAAATGCCATCCTCCAGAAGCTGGACCAC
  CCCAATGTGGTGAAGCTGGTGGAAGTCCTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_172226 unedited
  NNNCCTTACTCTGGACCGCGGGCCGCATGCTANGATCGAGTTTTTTTTTTTTTTTTTTTT
  AAGTTCATGTACTTTTTAGTGATAAATACACAGTATTTAACTTTATACACCTGATAAAAG
  GAAAATGCATAGTAGAAAGGGTCGGGAATGAAACAGAAGCATCGGGCATTGAATCGATCA
  CAGAGTAGAAAAATCTGCAGTCCCCAGAAACTCGGCCTCCAGCTGGAGAGGGGAACCAGC
  GTACCCTGAAACTTCCCTAGCACCTTGGAAGCAAGTGGAGGTCATGGTTCTTCCACTCGG
  CAACGTGAAGCTCCCCGCTGGAAGACAAGTGAGAGCGACAGGCCAGGCCTGTGTGTCCAC
  CTGCACAGGCATTCTCCTTGTTCCAGAAAGGCTCTGAGGACGGAAGACCTGCCTCTCAGG
  AAAGGCCAGACCAGTAGGGAGAGGCCTCCGCAGCCCCAAGTGTCAACAAGGGGCTCAATA
  AGGCTTTCTGGGAGCCACTGGCAGCTGGTGGGATGGAAGGGGGAGGTGGAAAAGGGCAGA
  GGAAATGGGAAGTGGTGGGGGGTTTTGTGCTTCCTTCGAGGCCACAAGTGCAGGCCACAG
  GTTGCTTACACCAAATTGGTCCCACAGATGAGCTAGCAATGGAAGAAATTATGGGGCGTC
  CTCTTTGCCCACTGGAAGAGCTGCTCATAACAGCACCTCCTTTCCTGACAGAGCTGGCTT
  TTGAAAAATCAATGTGCTCCAAGAGTGGCAGCTCAAATGCTCTGTGTTTACAGCCATCTT
  GGCTTATCCTTTTCATGGGGGGCAGGGCCTTTCCCAGCTTTTTTTGGGGTGTCTTCATTA
  AAGAAAAAAAAAGTCATCATTGTGGGTCTTCCCACCCACTGCCCCACAGCTGGGTGCTGN
  CTGAATGGCTGCATTCCTGGAAGAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_172226
• ORF Size: 1626 bp
• Insert Size: 4860
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_172226.1, NP_757380.1
• RefSeq Size: 4873
• RefSeq ORF: 1626
• Locus ID: 10645
• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors
• Protein Pathways: Adipocytokine signaling pathway
• Gene Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
  Transcript Variant: This variant (7) differs in the 5' UTR and also lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1. This isoform (2) is also encoded by variant 2.