PAR4 (PAWR) (NM_002583) Human Untagged Clone

CAT#: SC110969

PAWR (untagged)-Human PRKC, apoptosis, WT1, regulator (PAWR)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PAWR
• Synonyms: Par-4; PAR4
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC110969 sequence for NM_002583 edited (data generated by NextGen Sequencing)
  ATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTG
  GAGGAGTGGAAGGCGAAACGCGAGAAGATGCGCGCCAAGCAGAACCCCCCGGGCCCGGCC
  CCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGGGGCTCTGGGCACC
  CCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCA
  CCTGCCGTCCCCGGTCCCGGGGGCGTGAACTGCGCGGTCGGCTCCGCCATGCTGACGCGG
  GCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTCTGCCTCGGCTGCA
  CCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCG
  GGCCCCAGTGCCAGGAAAGGCAAGGGGCAGATCGAGAAGAGGAAGCTGCGGGAGAAGCGG
  CGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGTGCTTAGATGAGTACGAAGATGAT
  GAAGCAGGGCAGAAAGAGCGGAAACGAGAAGATGCAATTACACAACAGAACACTATACAG
  AATGAAGCTGTAAACTTACTAGATCCAGGCAGTTCCTATCTGCTACAGGAGCCACCTAGA
  ACAGTTTCAGGCAGATATAAAAGCACAACCAGTGTCTCTGAAGAAGATGTCTCAAGTAGA
  TATTCTCGAACAGATAGAAGTGGGTTCCCTAGATATAACAGGGATGCAAATGTTTCAGGT
  ACTCTGGTTTCAAGTAGCACACTGGAAAAGAAAATTGAAGATCTTGAAAAGGAAGTAGTA
  AGAGAAAGACAAGAAAACCTAAGACTTGTGAGACTGATGCAAGATAAAGAGGAAATGATT
  GGAAAACTCAAAGAAGAAATTGATTTATTAAATAGAGACCTAGATGACATAGAAGATGAA
  AATGAACAGCTAAAGCAGGAAAATAAAACTCTTTTGAAAGTTGTGGGTCAGCTGACCAGG
  TAG
  
  Clone variation with respect to NM_002583.2
  597 t=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002583 unedited
  TCCCGCCCCGTTGCCGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGA
  GCTTATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAAT
  TCGGCACGAGGGAGAAACTTTGCAGGGTGGGGACCCGGCGGCTGCTGGCCGGTAGTGACT
  GGTGGGCGCGCTCGAGGACTCCAAGGGGCGCAGCCCGGGGGCAGACCCTTGGGTCGGGCG
  GGGATCTTACGCTTCCCTTACCCGCCCCCTTTTGTCTTTCACCTCAGCCCCGCCGGCTGC
  TGTGGGAGCGGCGGCCGTCCCTCTCCTGGAGGTCGTCTCCTGGCATCCTCGGGGCCGCAG
  GAAGGAAGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCG
  GCCCCTTTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCA
  CCACAGACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATGCGCGCCAAGCAGAACC
  CCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGG
  NGGCTCTGGGCACCCCGGCGGCCGNCGCTGCCAACGAGCTCAACACAACCTCCCGGGCGG
  CGCGCCGGCCGCACCTGCCGTCCCCGTCCCGGGGGCGTGACTGCGNNCGTCGCTCCGCCA
  TGCTGACGCGGGCGGGCCCCGGCCGCNNGCGTTCGAGACGAACCCCCACCGNCTCTGCCT
  CGGNTGCACCGCCGCCCANCGTGACAAAGGAGAACCCGGACGCGTCCCANAAAGGGCAGA
  GCTCGGCCCCAGTGCCAGAANGGCAAGGGCANATCGAGAAAAGAACCTGCCGGAGACCGC
  GCTCACCGGCGGGTCACATCCTGCCGCAAN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002583 unedited
  NNCCGGTATATTATGGACCGCGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTTT
  TTTCTAAATAATAATATTTAATAGAAAAAAAATCTGTATAATTATTTAGAAGTAACTCTG
  TTTTTAAAATTTCAATGTTAGGAAGAAAATCCCTTAAATTTGAAATAGCGGAATATTCTC
  TCATATGAAAAAACTGTGTCCCAGTGTTATTCTTCAACTTAGAAATTAGGCAAAGTATTT
  TAGTACTATTTCTGCTTACATATTGTTTTGTATGAATGTTTTAAGTATGAATAATATTTT
  GGTTTTTAGTGTGCATGCTAATATAAAAATATGGATTTTTTTCTCCTACACTGACTTTGT
  ACACTTTCCAGGCCCGAAGAATAAAAAACTTTTAAAATATCCTGTGTTCACTAGCAAACC
  TTGGAACGATAAAAAAAGGTAGTACCTACATAAGAAATTTTACATTGAAATTACAATTGT
  ATGTTTTTCAGGAGTTAAAGTGATTCAATTTTTCAATATTCAAACACAAAATAGTAAATT
  TTTATTTACTATAGCACAATTCAAGTATTCTCTTAAATTTATATTTAGTCAACTAAAACA
  TGACAGTGACTTTATAAGAGCTTTCCTTTTAAAAGGTTGCTGTTATAAAAAAGTATGACT
  CTATTACTCTAAATGCTTAGAATAAGTGGAAAGAACAAATGACAGTAGACAAAAACCTTT
  ATGAGTGAGTCATCAACACATAAAAGGTTGCACACCTCAGTAATAGGACATGTGAAGGTA
  ACATCCCAAAAGTATTTGAACTCATGTAAACAAAGACTATGGTATTTCCTAGGGAGAAAA
  TGTNCTTCCCAGATAAAATATATTTCAACGGCTGTGACTTTTAACCATGTATTAGTTGGA
  TACCCN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002583
• ORF Size: 1023 bp
• Insert Size: 1750
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_002583.2, NP_002574.2
• RefSeq Size: 1967
• RefSeq ORF: 1023
• Locus ID: 5074
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]