PAR4 (PAWR) (NM_002583) Human Untagged Clone

CAT#: SC320836

PAWR (untagged)-Human PRKC, apoptosis, WT1, regulator (PAWR)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PAWR
• Synonyms: Par-4; PAR4
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002583 edited
  TGGGAGCGGCGGCCGTCCCTCTCCTGGAGGTCGTCTCCTGGCATCCTCGGGGCCGCAGGA
  AGGAAGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCGGC
  CCCTTTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACC
  ACAGACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATGCGCGCCAAGCAGAACCCC
  CCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGGG
  GCTCTGGGCACCCCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGC
  GCGCCGGCCGCACCTGCCGTCCCCGGTCCCGGGGGCGTGAACTGCGCGGTCGGCTCCGCC
  ATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTCT
  GCCTCGGCTGCACCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAG
  GGCAAGAGCTCGGGCCCCAGTGCCAGGAAAGGCAAGGGGCAGATCGAGAAGAGGAAGCTG
  CGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGTGCTTAGATGAG
  TACGAAGATGATGAAGCAGGGCAGAAAGAGCGGAAACGAGAAGATGCAATTACACAACAG
  AACACTATACAGAATGAAGCTGTAAACTTACTAGATCCAGGCAGTTCCTATCTGCTACAG
  GAGCCACCTAGAACAGTTTCAGGCAGATATAAAAGCACAACCAGTGTCTCTGAAGAAGAT
  GTCTCAAGTAGATATTCTCGAACAGATAGAAGTGGGTTCCCTAGATATAACAGGGATGCA
  AATGTTTCAGGTACTCTGGTTTCAAGTAGCACACTGGAAAAGAAAATTGAAGATCTTGAA
  AAGGAAGTAGTAAGAGAAAGACAAGAAAACCTAAGACTTGTGAGACTGATGCAAGATAAA
  GAGGAAATGATTGGAAAACTCAAAGAAGAAATTGATTTATTAAATAGAGACCTAGATGAC
  ATAGAAGATGAAAATGAACAGCTAAAGCAGGAAAATAAAACTCTTTTGAAAGTTGTGGGT
  CAGCTGACCAGGTAGAGGATTCAAGACTCAATGTGGAAAAAATATTTTAAACTACTGATT
  GAATGTTAATGGTCAATGCTAGCACAATATTCCTATGCTGCAATACATTAAAATAACTAA
  GCAAGTATATTTATTTCTAGCAAACAGATGTTTGTTTTCAAAATACTTCTTTTTCATTAT
  TGGTTTTAAAAAAGCATTATCCTTTTATCTCACAAATAAGTAATATCTTTCAGTTATTAA
  ATGATAGATAATGCCTTTTTGGTTTTGTGTGGTATTCAACTAATACATGGTTTAAAGTCA
  CAGCCGTTTGAATATATTTTATCTTGGTAGTACATTTTCTCCCTTAGGAATATACATAGT
  CTTTGTTTTACATGAGTTCAAATACTTTTGGGATGTTACCTTCACATGTCCTATTACTGA
  TGTGTGCAACCTTTTATGTGTTGATGACTCACTCATAAAGGTTTTTGTCTACTGTCATTT
  GTTCTTTCCACTTATTCTAAGCATTTAGAGTAATAGAGTCATACTTTTTTATAACAGCAA
  CCTTTTAAAAGGAAAGCTCTTATAAAGTCACTGTCATGTTTTAGTTGACTAAATATAAAT
  TTAAGAGAATACTTGAATTGTGCTATAGTAAATAAAAATTTACTATTTTGTGTTTGATAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002583.2 unedited
  CGCGATTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCCATTACGGCCGGGGTGGG
  AGCGGCGGCCGTCCCTCTCCTGGAGGTCGTCTCCTGGCATCCTCGGGGCCGCAGGAAGGA
  AGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCGGCCCCT
  TTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAG
  ACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATGCGCGCCAAGCAGAACCCCCCGG
  GCCCGGCCCCCCCGGGAGGGGGCAGCATCGACGCCGCTGGGAAGCCCCCCGCGGGGGCTC
  TGGGCACCCCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGC
  CGGCCGCACCTGCCGTCCCCGGTCCCGGGGGCGTGAACTGCGCGGTCGGCTCCGCCATGC
  TGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCACAGCCGCCTCTGCCT
  CGGCTGCACCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAAGGGC
  AAGAGCTCGGGCCCCAGTGCCAGGAAAGGCAAAGGGCAGATCGAGAAGAGGAAGCTGCGA
  GAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGTGCTTAGATGAGTAC
  GAAGATGATGAAGCAGGGCAGAAAGAGCGGAAACGAGAGATGCATTACCCAACAGAACCA
  CTTATACAGATGAGCTGTAACTTACTAGATCCAGGCAGTTCTATCTGCTACAGGGAGCCA
  CTAGAACAGTTCAGGCGATTTAAGCACACCAATGTCCTCTGGAGAAAGATGTCTCAAGTA
  GATATTTCCTCGAAACAGATAGACGTGGGGTTCCCTAGAAGTA
• Restriction Sites: Please inquire
• ACCN: NM_002583
• ORF Size: 1023 bp
• Insert Size: 1800
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_002583.2, NP_002574.2
• RefSeq Size: 1967
• RefSeq ORF: 1023
• Locus ID: 5074
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]