SPHK2 (NM_020126) Human Untagged Clone

CAT#: SC113181

SPHK2 (untagged)-Human sphingosine kinase 2 (SPHK2), transcript variant 1


  "NM_020126" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol SPHK2
Synonyms SK-2; SK 2; SPK-2; SPK 2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC113181 sequence for NM_020126 edited (data generated by NextGen Sequencing)
ATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGAGGCCAGACCAGGAGCTGACC
GGGAGCTGGGGCCACGGGCCTAGGAGCACCCTGGTCAGGGCTAAGGCCATGGCCCCGCCC
CCACCGCCACTGGCTGCCAGCACCCCGCTCCTCCATGGCGAGTTTGGCTCCTACCCAGCC
CGAGGCCCACGCTTTGCCCTCACCCTTACATCGCAGGCCCTGCACATACAGCGGCTGCGC
CCCAAACCTGAAGCCAGGCCCCGGGGTGGCCTGGTCCCGTTGGCCGAGGTCTCAGGCTGC
TGCACCCTGCGAAGCCGCAGCCCCTCAGACTCAGCGGCCTACTTCTGCATCTACACCTAC
CCTCGGGGCCGGCGCGGGGCCCGGCGCAGAGCCACTCGCACCTTCCGGGCAGATGGGGCC
GCCACCTACGAAGAGAACCGTGCCGAGGCCCAGCGCTGGGCCACTGCCCTCACCTGTCTG
CTCCGAGGACTGCCACTGCCCGGGGATGGGGAGATCACCCCTGACCTGCTACCTCGGCCG
CCCCGGTTGCTTCTATTGGTCAATCCCTTTGGGGGTCGGGGCCTGGCCTGGCAGTGGTGT
AAGAACCACGTGCTTCCCATGATCTCTGAAGCTGGGCTGTCCTTCAACCTCATCCAGACA
GAACGACAGAACCACGCCCGGGAGCTGGTCCAGGGGCTGAGCCTGAGTGAGTGGGATGGC
ATCGTCACGGTCTCGGGAGACGGGCTGCTCCATGAGGTGCTGAACGGGCTCCTAGATCGC
CCTGACTGGGAGGAAGCTGTGAAGATGCCTGTGGGCATCCTCCCCTGCGGCTCGGGCAAC
GCGCTGGCCGGAGCAGTGAACCAGCACGGGGGATTTGAGCCAGCCCTGGGCCTCGACCTG
TTGCTCAACTGCTCACTGTTGCTGTGCCGGGGTGGTGGCCACCCACTGGACCTGCTCTCC
GTGACGCTGGCCTCGGGCTCCCGCTGTTTCTCCTTCCTGTCTGTGGCCTGGGGCTTCGTG
TCAGATGTGGATATCCAGAGCGAGCGCTTCAGGGCCTTGGGCAGTGCCCGCTTCACACTG
GGCACGGTGCTGGGCCTCGCCACACTGCACACCTACCGCGGACGCCTCTCCTACCTCCCC
GCCACTGTGGAACCTGCCTCGCCCACCCCTGCCCATAGCCTGCCTCGTGCCAAGTCGGAG
CTGACCCTAACCCCAGACCCAGCCCCGCCCATGGCCCACTCACCCCTGCATCGTTCTGTG
TCTGACCTGCCTCTTCCCCTGCCCCAGCCTGCCCTGGCCTCTCCTGGCTCGCCAGAACCC
CTGCCCATCCTGTCCCTCAACGGTGGGGGCCCAGAGCTGGCTGGGGACTGGGGTGGGGCT
GGGGATGCTCCGCTGTCCCCGGACCCACTGCTGTCTTCACCTCCTGGCTCTCCCAAGGCA
GCTCTACACTCACCCGTCTCCGAAGGGGCCCCCGTAATTCCCCCATCCTCTGGGCTCCCA
CTTCCCACCCCTGATGCCCGGGTAGGGGCCTCCACCTGCGGCCCGCCCGACCACCTGCTG
CCTCCGCTGGGCACCCCGCTGCCCCCAGACTGGGTGACGCTGGAGGGGGACTTTGTGCTC
ATGTTGGCCATCTCGCCCAGCCACCTAGGCGCTGACCTGGTGGCAGCTCCGCATGCGCGC
TTCGACGACGGCCTGGTGCACCTGTGCTGGGTGCGTAGCGGCATCTCGCGGGCTGCGCTG
CTGCGCCTTTTCTTGGCCATGGAGCGTGGTAGCCACTTCAGCCTGGGCTGTCCGCAGCTG
GGCTACGCCGCGGCCCGTGCCTTCCGCCTAGAGCCGCTCACACCACGCGGCGTGCTCACA
GTGGACGGGGAGCAGGTGGAGTATGGGCCGCTACAGGCACAGATGCACCCTGGCATCGGT
ACACTGCTCACTGGGCCTCCTGGCTGCCCGGGGCGGGAGCCCTGA

Clone variation with respect to NM_020126.4
>OriGene 5' read for NM_020126 unedited
TCACATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGGCACCAGCCGGAGACCCGG
CGGGCCCAGTGTTGGAGAGCTGAAGGTCAGGCCAGGACAGTGAGACCTGACTCCTTGCTC
CTACCAGCCTACTATGGCTTAAGACCCAGGGCCAGGGTCCCGTTGATGTAACAGAGCAGA
GGACCAGCAGATGAATGGACACCTTGAAGCAGAGGAGCAGCAGGACCAGAGGCCAGACCA
GGAGCTGACCGGGAGCTGGGGCCACGGGCCTAGGAGCACCCTGGTCAGGGCTAAGGCCAT
GGCCCCGCCCCCACCGCCACTGGCTGCCAGCACCCCGCTCCTCCATGGCGAGTTTGGCTC
CTACCCAGCCCGAGGCCCACGCTTTGCCCTCACCCTTACATCGCAGGCCCTGCACATACA
GCGGCTGCGCCCCAAACCTGAAGCCAGGCCCCGGGGTGGCCTGGTCCCGTTGGCCGAGGT
CTCAGGCTGCTGCACCCTGCGAAGCCGCAGCCCCTCAGACTCAGCGGCCTACTTCTGCAT
CTACACCTACCCTCGGGGCCGGCGCGGGGCCCGGCGCAGAGCCACTCGCACCTTCCGGGC
AGATGGGGCCGCCACCTACGAAGAGAACCGTGCCGAAGCCCAGCGCTGGGCCACTGCCCT
CACCTGTCTGCTCCGAGGACTGCCACTGCCCGGGGATGGGGAGATCACCCCTGACCTGCT
ACCTCGGCCGCCCCGGTTGCTTCTATTGGTCAATCCCTTTGGGGGTCGGGGCCTGGCCTG
GCAGTGGTGTAAGAAACACGTGCTTCCCATGATCTCTGAAGCTGGGCTGGTCTTCAAACT
CATCCAGACAGAACGACAGAACCACGCCGGGAGCCTGGTCANGGGCTGAACCTGGATGAG
TGGATGGCATCGTACGGTCTCGGGAAACGGCTGCTCATGAGTATTGA
>OriGene 3' read for NM_020126 unedited
AGCTTGTACGCGGCCGCATTCTANATCGAGTTTTTTTTTTTTTTTTTTGAGAGGAATGAA
GCGACTGCCTTTATTGCATAGACCTTTTCAATTGCTTTTTAGATTGGGGACGGAGGACGC
GCATGAGACGAACAGGGGATATGAATTTCCCCGCCCCCACCCGCGGGGAGAGGAACATTA
GTGCAAATCCTAGCGCCGGCCCCGGGGAACCTGCCCCTCCTGGGCTGATTGGCCAGCTAA
ATGGAGGCACCGGAGTGGATGGGGCGAGGCTGCGGGCCCTGACCGGCCGACTCACTGAGG
CCTACCCCAGCCAGTACATTCCAGGTCCTGTCATTGGGCGACGCGTAAAATAGACTCCGC
CCTCAGCCATCCTGGCCGGGTAGGAGCAGGTGGCAAGCGTCAGGACTGAGCCCTGCCCCG
TAAGGGCGGCCCCAGATCAGACGCCAGGCCCCGCCCTCATTGATCAGGCACTACCCTCGG
GACGAGCCCATTTCTCTTTAACCGTGACGACGCCCACCTTCCAGCATCACGTCTGGTCCC
ATGAAAGCGAGCGCAATCCTGAGACGGGGCCAGGGCCCCTGCCACCACAACTCTAGCAGC
CAGGCCACACCCNCTAGCTCAGGCTCCGCCCCATTGGAATGTANGCCCCGCCCCCCGCGG
GTACAAGCTTGGTTAGTTTCAAGGCTCCCGCCCCGGGCAGCCAGNAGGCCCAGTGAGCAG
TGTACCGATGCCAGGGTGCATCTGTGCCTGTAGCGGCCATACTCCAACTGCTCCCCGTCC
ACTGTGAGCAGCCGCCGTGTGTGAGCGGCTCTAGGCGGAGGGCCAGGGCCGGGGCGTATC
CCACCTGGCGACAGCCCAGGCTGGAGTGGGCTACCACGCTCCATGGCCAAAAAAAGGCGC
AGCAACGCAGCCCCGCGAGATGCCGCTACGCACCCAGCCAGGTGCACCAAGCCGTCGTCG
AACG
Restriction Sites NotI-NotI     
ACCN NM_020126
ORF Size 1965 bp
Insert Size 2900
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_020126.3, NP_064511.2
RefSeq Size 3012
RefSeq ORF 1965
Locus ID 56848
Domains DAGKc
Protein Families Druggable Genome
Protein Pathways Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Metabolic pathways, Sphingolipid metabolism, VEGF signaling pathway
Gene Summary This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).

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