PCSK7 (NM_004716) Human Untagged Clone

CAT#: SC117224

PCSK7 (untagged)-Human proprotein convertase subtilisin/kexin type 7 (PCSK7)


  "NM_004716" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PCSK7
Synonyms LPC; PC7; PC8; SPC7
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC117224 sequence for NM_004716 edited (data generated by NextGen Sequencing)
ATGCCGAAGGGGAGGCAGAAAGTGCCACACTTGGATGCCCCCCTGGGCCTGCCCACCTGC
CTCTGGCTGGAATTAGCCGGGCTCTTCTTACTGGTTCCCTGGGTCATGGGCCTGGCAGGG
ACAGGTGGGCCTGATGGCCAGGGCACAGGGGGGCCGAGCTGGGCTGTGCACCTGGAAAGC
CTGGAAGGTGACGGGGAGGAAGAGACTCTGGAGCAGCAGGCGGATGCCTTGGCCCAGGCA
GCAGGGCTGGTGAATGCTGGACGCATCGGAGAGCTTCAGGGGCACTACCTCTTTGTCCAG
CCTGCTGGGCACAGGCCGGCCCTGGAGGTGGAGGCCATCCGGCAGCAGGTGGAGGCTGTG
TTGGCTGGGCATGAAGCTGTGCGCTGGCACTCAGAGCAGAGGCTGCTAAGGCGGGCCAAG
CGCAGCGTCCACTTCAACGACCCCAAGTACCCGCAGCAATGGCACCTGAATAACCGACGG
AGCCCGGGCAGGGACATCAACGTGACGGGTGTGTGGGAACGCAATGTGACTGGGCGAGGG
GTGACGGTGGTGGTAGTGGATGACGGAGTGGAACACACCATCCAGGACATTGCACCCAAC
TATAGCCCTGAGGGTAGCTATGACCTCAACTCTAATGACCCTGACCCCATGCCCCACCCG
GATGTGGAGAATGGCAACCACCATGGCACGCGATGTGCAGGAGAGATCGCGGCTGTGCCC
AACAACAGCTTCTGTGCCGTGGGCGTGGCCTACGGGAGCCGCATCGCAGGTATCCGGGTA
CTGGATGGACCTCTCACAGACAGCATGGAGGCAGTGGCGTTCAACAAGCACTATCAGATC
AATGACATCTACAGCTGCAGCTGGGGACCAGATGACGATGGGAAGACAGTGGATGGCCCC
CATCAGCTTGGAAAGGCTGCCTTACAACATGGGGTGATTGCTGGTCGCCAGGGCTTTGGG
AGCATCTTTGTGGTAGCCAGTGGCAACGGAGGCCAACACAACGACAACTGCAACTACGAT
GGCTACGCCAACTCCATCTACACCGTCACCATAGGAGCTGTGGATGAGGAGGGACGCATG
CCTTTCTATGCAGAAGAATGTGCCTCCATGCTGGCAGTCACCTTCAGTGGTGGGGACAAG
ATGCTTCGGAGCATTGTGACCACTGACTGGGACCTTCAGAAGGGCACTGGCTGCACTGAG
GGCCACACAGGGACCTCAGCTGCAGCGCCTCTGGCAGCTGGCATGATAGCCTTAATGCTG
CAGGTGCGGCCCTGCCTCACGTGGCGTGACGTCCAGCACATCATTGTCTTCACAGCCACC
CGGTATGAGGATCGCCGTGCAGAGTGGGTCACCAACGAGGCAGGCTTCAGCCATAGCCAC
CAGCACGGTTTCGGCCTCCTCAACGCCTGGAGGCTCGTGAATGCAGCCAAGATCTGGACA
TCTGTCCCTTACTTAGCATCCTACGTCAGTCCCGTGTTAAAAGAAAACAAGGCGATTCCG
CAGTCCCCCCGTTCCCTGGAGGTCCTGTGGAATGTCAGCAGGATGGACCTGGAGATGTCA
GGGCTGAAGACCCTGGAGCATGTGGCAGTGACAGTCTCCATCACTCACCCACGGCGCGGC
AGCTTGGAGCTGAAGCTGTTCTGCCCCAGTGGCATGATGTCCCTCATCGGCGCCCCCCGC
AGCATGGACTCGGATCCCAACGGCTTCAATGACTGGACCTTCTCCACTGTGCGATGCTGG
GGGGAGAGAGCCCGAGGGACCTACAGGCTGGTCATCAGGGATGTCGGGGATGAGTCATTC
CAGGTCGGCATCCTCCGGCAATGGCAGCTGACCCTATATGGCTCTGTGTGGAGTGCAGTA
GACATCAGGGACAGACAAAGGCTGTTAGAGAGTGCCATGAGTGGAAAATACCTGCACGAT
GACTTCGCCCTGCCCTGCCCACCGGGGCTGAAAATTCCTGAGGAAGATGGTTACACCATC
ACCCCCAACACCCTCAAGACCCTGGTGCTGGTAGGCTGTTTCACCGTCTTCTGGACCGTT
TACTACATGCTGGAAGTATATTTGAGCCAGAGGAATGTGGCTTCCAATCAAGTTTGTAGG
AGTGGACCCTGCCACTGGCCCCATCGGAGCCGGAAAGCCAAGGAGGAAGGGACAGAGCTA
GAATCAGTGCCACTTTGCAGCAGCAAGGATCCAGACGAAGTGGAAACAGAGAGCAGGGGC
CCTCCCACCACCTCTGACCTCCTTGCCCCAGACCTGCTGGAGCAAGGGGACTGGAGCCTG
TCCCAGAACAAGAGCGCCCTGGACTGCCCTCATCAGCACCTAGACGTACCGCACGGGAAG
GAGGAGCAGATCTGCTGA

Clone variation with respect to NM_004716.2
1770 t=>g;2037 t=>c
>OriGene 5' read for NM_004716 unedited
TCCCCGCCCTGTTGNCGCAAAGGGCGGTATGCGTGTACGGTGGGAGGTCTATATAAGCAG
AGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAA
TTCGGCACGAGGGCGGCGGCAGCTGCGGCGGGGCCGGTCTGTAGCCTTTGCTGAGTCAAC
ACTACTCACAGTGAAAGTGATGCCTTTTCTCCATTTGCACAACATGAGTGTGACGTGGTT
AGCCAGACCAGGAGCTCAACCTCATGTAGAATCCAGTCCACTGCTCTGATGCCGAAGGGG
AGGCAGAAAGTGCCACACTTGGATGCCCCCCTGGGCCTGCCCACCTGCCTCTGGCTGGAA
TTAGCCGGGCTCTTCTTACTGGTTCCCTGGGTCATGGGCCTGGCAGGGACAGGTGGGCCT
GATGGCCAGGGCACAGGGGGGCCGAGCTGGGCTGTGCACCTGGAAAGCCTGGAAGGTGAC
GGGGAGGAAGAGACTCTGGAGCAGCAGGCGGATGCCTTGGCCCAGGCAGCAGGGCTGGTG
AATGCTGGACGCATCGGAGAGCTTCAGGGGCACTACCTCTTTGTCCAGCCTGCTGGGCAC
AGGCCGGCCCTGGAGGTGGAGGCCATCCGGCAGCAGGTGGAGGCTGTGTTGGCTGGGCAT
GAAGCTGTGCGCTGGCACTCAGAGCAGANGCTGCTAAGGCGGGCCAAGCGCAGCGTTCAC
TTCAACGACCCCAAGTACCCGCAGCAATGGCACCTGAATAACCGACGGAGCCCGGGCAGG
GACATCAACGTGACGGGTGTGTGGGAAACGCATGTGACTGGGCGAAGGGTGACCGTGGTG
GTATTGGATGACCGAGTGGAACACACATCCAGGACATGCACCCAACTTAGCCCTGAGGTA
GCTATGACCTCACTCTATGACCCTGACCCTGCCCCACCCGGTGTGGAGGATGGNCACCCC
ATGCCCCCG
>OriGene 3' read for NM_004716 unedited
GTATAGCTATGNNACCGCGGCCGCAATCTAGNGTCGAGTTTTTTTTTTTTTTTTTTGTTT
GGAAGGTTTTTATTTTGGAAAAGCTGTGCAGAAAAAAATCAAGAAAATGTTGCTGTGAAA
AGAGAAAAACAAATCTTAAGCATTAAAAAAAATTCAACCAACTAGCTCAGAAGAGGGGAG
AAGGCCAAGGTTGAGAGAAGAGTCACAGCCTGTCAGGCAGATAGCTGGCCTCCGGCGGGA
AGGCCATTTCCCTGAGCACTTGCAGAGGAAGACAGGGTGGTGGCAGGACTGGAGTGGCAG
TGGCTCCCAAGGCTCTCTCCTCCAACATGTGCATCTGCCATCTGCTCTGCAGTCCTGCCG
CAGGATTCCCTAGTGAAGCAGCTCAAGCCTGGGGGAGCCGTGTGTATCCCAGCTGTGCCG
GCAGCATCATACCAATCGTGGGGGTGGTGAAGGAGCCAGGGGTTCATTCATGGGTGGTTT
CTGATCAGGCATCTTGGGAATGGATAATGGAGGCAGCCGCTTTCAGGACAGGCATGTTCA
GGGGCTCCTCCCAGCCTCTACCCCGAAGTCCTCTTTCCAAGTGACCCCAGTGATGTTTCC
CTTGAGATGCGCTCCTGGCTATGGGAAGGACCCTCTCAACTTATATGTGGAAGGGGGTCC
CCCCTGCTTGGGGGACCAAGCACCTGGCTTGGCCCCAAAAAATGAGGGTGGGGGGCAAAC
CAAAGGGGGGGCCCAATCCCCGTGCAAACCCTCTTACCAAAACGCCCCGTTGGGTGGGGG
CGGAACCTGGGGTCTGAACCACATCTCTTGGGGGAAATCCCCCCCCTTTTTGTTTTAAAA
AGGCCCTCACCCCTTTTTGGTGGGGCCCAGGAAGGCCCCCACTTCCCCGAGGTTAGGCCC
TCCAAACG
Restriction Sites ECoRI-NOT     
ACCN NM_004716
ORF Size 2358 bp
Insert Size 4000
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_004716.2, NP_004707.2
RefSeq Size 3497
RefSeq ORF 2358
Locus ID 9159
Domains Peptidase_S8, P_proprotein
Protein Families Druggable Genome, Protease, Transmembrane
Gene Summary This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]

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