PCSK7 (NM_004716) Human Untagged Clone

CAT#: SC323814

PCSK7 (untagged)-Human proprotein convertase subtilisin/kexin type 7 (PCSK7)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PCSK7
• Synonyms: LPC; PC7; PC8; SPC7
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004716.2 CACTGCTCCTCCGGCTCCCGGGAAGCCGCGAGTTTCCGCAGGGAGGCGGCGGCAGCTGCG
  GCGGGGCCGGTCTGTAGCCTTTGCTGAGTCAACACTACTCACAGTGAAAGTGATGCCTTT
  TCTCCATTTGCACAACATGAGTGTGACGTGGTTAGCCAGACCAGGAGCTCAACCTCATGT
  AGAATCCAGTCCACTGCTCTGATGCCGAAGGGGAGGCAGAAAGTGCCACACTTGGATGCC
  CCCCTGGGCCTGCCCACCTGCCTCTGGCTGGAATTAGCCGGGCTCTTCTTACTGGTTCCC
  TGGGTCATGGGCCTGGCAGGGACAGGTGGGCCTGATGGCCAGGGCACAGGGGGGCCGAGC
  TGGGCTGTGCACCTGGAAAGCCTGGAAGGTGACGGGGAGGAAGAGACTCTGGAGCAGCAG
  GCGGATGCCTTGGCCCAGGCAGCAGGGCTGGTGAATGCTGGACGCATCGGAGAGCTTCAG
  GGGCACTACCTCTTTGTCCAGCCTGCTGGGCACAGGCCGGCCCTGGAGGTGGAGGCCATC
  CGGCAGCAGGTGGAGGCTGTGTTGGCTGGGCATGAAGCTGTGCGCTGGCACTCAGAGCAG
  AGGCTGCTAAGGCGGGCCAAGCGCAGCGTCCACTTCAACGACCCCAAGTACCCGCAGCAA
  TGGCACCTGAATAACCGACGGAGCCCGGGCAGGGACATCAACGTGACGGGTGTGTGGGAA
  CGCAATGTGACTGGGCGAGGGGTGACGGTGGTGGTAGTGGATGACGGAGTGGAACACACC
  ATCCAGGACATTGCACCCAACTATAGCCCTGAGGGTAGCTATGACCTCAACTCTAATGAC
  CCTGACCCCATGCCCCACCCGGATGTGGAGAATGGCAACCACCATGGCACGCGATGTGCA
  GGAGAGATCGCGGCTGTGCCCAACAACAGCTTCTGTGCCGTGGGCGTGGCCTACGGGAGC
  CGCATCGCAGGTATCCGGGTACTGGATGGACCTCTCACAGACAGCATGGAGGCAGTGGCG
  TTCAACAAGCACTATCAGATCAATGACATCTACAGCTGCAGCTGGGGACCAGATGACGAT
  GGGAAGACAGTGGATGGCCCCCATCAGCTTGGAAAGGCTGCCTTACAACATGGGGTGATT
  GCTGGTCGCCAGGGCTTTGGGAGCATCTTTGTGGTAGCCAGTGGCAACGGAGGCCAACAC
  AACGACAACTGCAACTACGATGGCTACGCCAACTCCATCTACACCGTCACCATAGGAGCT
  GTGGATGAGGAGGGACGCATGCCTTTCTATGCAGAAGAATGTGCCTCCATGCTGGCAGTC
  ACCTTCAGTGGTGGGGACAAGATGCTTCGGAGCATTGTGACCACTGACTGGGACCTTCAG
  AAGGGCACTGGCTGCACTGAGGGCCACACAGGGACCTCAGCTGCAGCGCCTCTGGCAGCT
  GGCATGATAGCCTTAATGCTGCAGGTGCGGCCCTGCCTCACGTGGCGTGACGTCCAGCAC
  ATCATTGTCTTCACAGCCACCCGGTATGAGGATCGCCGTGCAGAGTGGGTCACCAACGAG
  GCAGGCTTCAGCCATAGCCACCAGCACGGTTTCGGCCTCCTCAACGCCTGGAGGCTCGTG
  AATGCAGCCAAGATCTGGACATCTGTCCCTTACTTAGCATCCTACGTCAGTCCCGTGTTA
  AAAGAAAACAAGGCGATTCCGCAGTCCCCCCGTTCCCTGGAGGTCCTGTGGAATGTCAGC
  AGGATGGACCTGGAGATGTCAGGGCTGAAGACCCTGGAGCATGTGGCAGTGACAGTCTCC
  ATCACTCACCCACGGCGCGGCAGCTTGGAGCTGAAGCTGTTCTGCCCCAGTGGCATGATG
  TCCCTCATCGGCGCCCCCCGCAGCATGGACTCGGATCCCAACGGCTTCAATGACTGGACC
  TTCTCCACTGTGCGATGCTGGGGGGAGAGAGCCCGAGGGACCTACAGGCTTGTCATCAGG
  GATGTCGGGGATGAGTCATTCCAGGTCGGCATCCTCCGGCAATGGCAGCTGACCCTATAT
  GGCTCTGTGTGGAGTGCAGTAGACATCAGGGACAGACAAAGGCTGTTAGAGAGTGCCATG
  AGTGGAAAATACCTGCACGATGACTTCGCCCTGCCCTGCCCACCGGGGCTGAAAATTCCT
  GAGGAAGATGGTTACACCATCACCCCCAACACCCTCAAGACCCTGGTGCTGGTAGGCTGT
  TTCACCGTCTTCTGGACTGTTTACTACATGCTGGAAGTATATTTGAGCCAGAGGAATGTG
  GCTTCCAATCAAGTTTGTAGGAGTGGACCCTGCCACTGGCCCCATCGGAGCCGGAAAGCC
  AAGGAGGAAGGGACAGAGCTAGAATCAGTGCCACTTTGCAGCAGCAAGGATCCAGACGAA
  GTGGAAACAGAGAGCAGGGGCCCTCCCACCACCTCTGACCTCCTTGCCCCAGACCTGCTG
  GAGCAAGGGGACTGGAGCCTGTCCCAGAACAAGAGCGCCCTGGACTGCCCTCATCAGCAC
  CTAGACGTACCGCACGGGAAGGAGGAGCAGATCTGCTGACCTCAGGGCCTGACAGTGTGG
  GACAGGCTCTTCTTTCCCAAAATTAGGGAGCTCTTGACAGAAAGCAGTTCTGATGCTTAC
  ATCTGGAATCTGAGGCATCCTCTGACTCCACTCAAAGAGGGTGAGGGCCTTCTTAAGATA
  CAAATGGTGGAGGATTGCTGCCAGAGAAGTCTGGTCAGAGCCACAGGGTCTGCCTCCAGC
  CAAACGGGAGCTTTTGGTGAGAAGGTGTTGGACAGGGGATTGGCGCCCCCCTTTGGTTTG
  GCCTCCATCCTCATCTCTCTTGGGCCAAGCCAGCTGCCTAGGTCCCCCAAGCATGGGGGA
  CCCCTTCCCACATATAAGTTGAGAAGGTGCCTGCCATAGCCAGGAGCGCATCTCAATGGA
  AACATCACTGGGGTCACTTGGGAAGAGGACTTCGGGGTAGAGGCTGGGAGGAGCCCCTGG
  ACATGCCTGTCCTGAAAGCGGCTGCCTCCATTATCCATTCCCAAGATGCCTGATCAGAAA
  CCAACCATGAATGAACCCCTGGCTCCTTCACCACCCCCACGATTGGTATGATGCTGCCGG
  CACAGCTGGGATACACACGGCTCCCCCAGGCCTGAGCTGCTTCACTAGGGAATCCTGCGG
  CAGGACTGCAGAGCAGATGGCAGATGCACATGTTGGAGGAGAGAGCCTTGGGAGCCACTG
  CCACTCCAGTCCTGCCACCACCCTGTCTTCCTCTGCAAGTGCTCAGGGAAATGGCCTTCC
  CGCCGGAGGCCAGCTATCTGCCTGACAGGCTGTGACTCTTCTCTCAACCTTGGCCTTCTC
  CCCTCTTCTGAGCTAGTTGGTTGAATTTTTTTTAATGCTTAAGATTTGTTTTTCTCTTTT
  CACAGCAACATTTTCTTGAATTTTTTTCTGCACAGCTTTTCCAAAATAAAAACCTTCCAA
  ACAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004716.2 unedited
  CACACAACGGTAAAACGAATTACTAAAGGGCGGCCGGCGAATCGCGGCGCCGCCGGTACC
  GGTTCCGGAATTTCCCGGGATATCGTCGACCCACGCGTTCCGCACTTGCTCCTCCGGCTC
  CCGGGAAGCCGCGAGTTTCCGCAGGGAGGCGGCGGCAGCTGCGGCGGGGCCGGTCTGTAG
  CCTTTGCTGAGTCAACACTACTCACAGTGAAAGTGATGCCTTTTCTCCATTTGCACAACA
  TGAGTGTGACGTGGTTAGCCAGACCAGGAGCTCAACCTCATGTAGAATCCAGTCCACTGC
  TCTGATGCCGAAGGGGAGGCAGAAAGTGCCACACTTGGATGCCCCCCTGGGCCTGCCCAC
  CTGCCTCTGGCTGGAATTAGCCGGGCTCTTCTTACTGGTTCCCTGGGTCATGGGCCTGGC
  AGGGACAGGTGGGCCTGATGGCCAGGGCACAGGGGGGCCGAGCTGGGCTGTGCACCTGGA
  AAGCCTGGAAGGTGACGGGGAGGAAGAGACTCTGGAGCAGCAGGCGGATGCCTTGGCCCA
  GGCAGCAGGGGCTGGTGAATGCTGGACGCATCGGAGAGCTTCAGGGGCACTACCTCTTTG
  TCCAGCCTGCTGGGCACAGACCGGCCCTGGAGGTGAATGCATTCAGACAGCAGGTGGGAG
  GCAGAGTTGCTGTGAAGGCAACTGGCACCAGGCACATACGCAGATAATTATAGGGAGTCA
  ATCACCAGAGAGACGGTGTGCGAGCGTAGTGGAATAAGATGGA
• Restriction Sites: ECoRI-NOT
• ACCN: NM_004716
• ORF Size: 2358 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004716.2, NP_004707.2
• RefSeq Size: 3497
• RefSeq ORF: 2358
• Locus ID: 9159
• Domains: Peptidase_S8, P_proprotein
• Protein Families: Druggable Genome, Protease, Transmembrane
• Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]