PLK3 (NM_004073) Human Untagged Clone

CAT#: SC117577

PLK3 (untagged)-Human polo-like kinase 3 (PLK3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PLK3
• Synonyms: CNK; FNK; PLK-3; PRK
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_004073 edited
  ATGGAGCCTGCCGCCGGTTTCCTGTCTCCGCGCCCCTTCCAGCGTGCGGCCGCCGCGCCC
  GCTCCCCCGGCCGGGCCCGGGCCGCCTCCGAGTGCCTTGCGCGGACCTGAGCTGGAGATG
  CTGGCCGGGCTACCGACGTCAGACCCCGGGCGCCTCATCACGGACCCGCGCAGCGGCCGC
  ACCTACCTCAAAGGCCGCTTGTTGGGCAAGGGGGGCTTCGCCCGCTGCTACGAGGCCACT
  GACACAGAGACTGGCAGCGCCTACGCTGTCAAAGTCATCCCGCAGAGCCGCGTCGCCAAG
  CCGCATCAGCGCGAGAAGATCCTAAATGAGATTGAGCTGCACCGAGACCTGCAGCACCGC
  CACATCGTGCGTTTTTCGCACCACTTTGAGGACGCTGACAACATCTACATTTTCTTGGAG
  CTCTGCAGCCGAAAGTCCCTGGCCCACATCTGGAAGGCCCGGCACACCCTGTTGGAGCCA
  GAAGTGCGCTACTACCTGCGGCAGATCCTTTCTGGCCTCAAGTACTTGCACCAGCGCGGC
  ATCTTGCACCGGGACCTCAAGTTGGGAAATTTTTTCATCACTGAGAACATGGAACTGAAG
  GTGGGGGATTTTGGGCTGGCAGCCCGGTTGGAGCCTCCGGAGCAGAGGAAGAAGACCATC
  TGTGGCACCCCCAACTATGTGGCTCCAGAAGTGCTGCTGAGACAGGGCCACGGCCCTGAG
  GCGGATGTATGGTCACTGGGCTGTGTCATGTACACGCTGCTCTGCGGGAGCCCTCCCTTT
  GAGACGGCTGACCTGAAGGAGACGTACCGCTGCATCAAGCAGGTTCACTACACGCTGCCT
  GCCAGCCTCTCACTGCCTGCCCGGCAGCTCCTGGCCGCCATCCTTCGGGCCTCACCCCGA
  GACCGCCCCTCTATTGACCAGATCCTGCGCCATGACTTCTTTACCAAGGGCTACACCCCC
  GATCGACTCCCTATCAGCAGCTGCGTGACAGTCCCAGACCTGACACCCCCCAACCCAGCT
  AGGAGTCTGTTTGCCAAAGTTACCAAGAGCCTCTTTGGCAGAAAGAAGAAGAGTAAGAAT
  CATGCCCAGGAGAGGGATGAGGTCTCCGGTTTGGTGAGCGGCCTCATGCGCACATCCGTT
  GGCCATCAGGATGCCAGGCCAGAGGCTCCAGCAGCTTCTGGCCCAGCCCCTGTCAGCCTG
  GTAGAGACAGCACCTGAAGACAGCTCACCCCGTGGGACACTGGCAAGCAGTGGAGATGGA
  TTTGAAGAAGGTCTGACTGTGGCCACAGTAGTGGAGTCAGCCCTTTGTGCTCTGAGAAAT
  TGTATAGCCTTCATGCCCCCAGCGGAACAGAACCCGGCCCCCCTGGCCCAGCCAGAGCCT
  CTGGTGTGGGTCAGCAAGTGGGTTGACTACTCCAATAAGTTCGGCTTTGGGTATCAACTG
  TCCAGCCGCCGTGTGGCTGTGCTCTTCAACGATGGCACACATATGGCCCTGTCGGCCAAC
  AGAAAGACTGTGCACTACAATCCCACCAGCACAAAGCACTTCTCCTTCTCCGTGGGTGCT
  GTGCCCCGGGCCCTGCAGCCTCAGCTGGGTATCCTGCGGTACTTCGCCTCCTACATGGAG
  CAGCACCTCATGAAGGGTGGAGATCTGCCCAGTGTGGAAGAGGTAGAGGTACCTGCTCCG
  CCCTTGCTGCTGCAGTGGGTCAAGACGGATCAGGCTCTCCTCATGCTGTTTAGTGATGGC
  ACTGTCCAGGTGAACTTCTACGGGGACCACACCAAGCTGATTCTCAGTGGCTGGGAGCCC
  CTCCTTGTGACTTTTGTGGCCCGAAATCGTAGTGCTTGTACTTACCTCGCTTCCCACCTT
  CGGCAGCTGGGCTGCTCTCCAGACCTGCGGCAGCGACTCCGCTATGCTCTGCGCCTGCTC
  CGGGACCGCAGCCCAGCCTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004073 unedited
  GCAAGAATTTGTAATACGACNACTATAGGGCGGCCGCGAATTCGCACCAGGCAAATCCAG
  GCAGCGCCACGCGCGGCCGGGGCCGGGCGGAACCGATAAGCCGGGACCGCGCTGCGACGC
  GCCGGCCGCATGGAGCCTGCCGCCGGTTTCCTGTCTCCGCGCCCCTTCCAGCGTGCGGAC
  GCCGCGCCCGCTCCCCCGGCCGGGCCCGGGCCGCCTCCGAGTGCCTTGCGCGGACCTGAG
  CTGGAGATGCTGGCCGGGCTACCGACGTCAGACCCCGGGCGCCTCATCACGGACCCGCGC
  AGCGGCCGCACCTACCTCAAAGGCCGCTTGTTGGGCAAGGGGGGCTTCGCCCGCTGCTAC
  GAGGCCACTGACACAGATACTGGCATCGCCTACGCTGTCAAAGTCATCCCGCATAGCCGC
  GTCGCCAAGCCGCATCATCGCGAGAAGATCCTAAATGAGATTGAGCTGCACCGAGACCTG
  CAGCACCGCCACATCGTGCGTTTTTCGCACCACTTTGAGGACGCTGACAACATCTACATT
  TTCTTGGAGCTCTGCAGCCGAAAGTCCCTGGCCCACATCTGGAATGCCCGGCACACCCTG
  TTGGAGCCAGAAGTGCGCTACTACCTGCGGCAGATCCTTTCTGGCCTCAAGTACTTGCAC
  CAGCGCGGCATCTTGCACCGGGACCTCAAGTTGTGAAATTCTTTCATCACTGAGAACATG
  GAACTGAAGGTGGGGGATTNTGAGCTGGCATCCCAGTTGGATCCTTCGGAGCAAAGGATG
  AGACCATCTGTGGCACCCACAACTATGTGGCTNCATAAGTGCTGCTGATACATGACCACN
  GNCCTAGAGCGGATGTATGGTCACTGGGCTGTGTCATGTACACACTGCTCTAGCGGAGCC
  CCTCCCTTGAGACNGCTGACCTGNAGGAGACCTACAGCTGCATCAAGCAGGTTCACTACA
  CGCTGNCTGGCANNCTNTACTGNCTGGCAGGNAGNTCTGGNCGCTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004073 unedited
  TTTCCGCCAATAGCTTGNACCGCGCCGCTTTCTANNGATCGATTTTTTTTTTTTTTTTTT
  TTTTTTCCAATTCTGCAAAATTGTTTATTATCCTAGGAGGAGGCCCCCCTGGGGCTCACA
  TCCCAATAAATAAGTGTCTGACAATAAATAAAAGTGGTCCATAAATAACGCCCCCTAGCT
  GGGAGCTAAGGCTCAGGCTTATCTTGGAGATGGGGTAGGAGCCAGCGAAGACAAGCCGCC
  CCCAACTCCAGTAAAGCTGGTCCCTGATTCCCTGGGGGATTCGGCCCAAAGCCCCCAGTG
  AGGCACCAAAGGAAGGGGGAAGGCCACAAAGGCAAGGGCCAGAGCCTGACAGGCACAGGC
  CTCAGGCCTCAGGGCTTGGGTCCTAGGCTGGGCTGCGGTCCCGGAGCAGGCGCAGAATCA
  TAGCGGAGTCGCTGCCGCAGGTCTGGAGAGCAGCCCAGCTGCCGAAGGTGGGAAGCGAGG
  TAAGTACAAACACTACGATTTCGGGCCACAAAAGTCACAAGGAGGGGCTCCCAGCCACTG
  AGAATCAGCTTGGTGTGGTCCCCGTAGAAGTTCACCTGGACAGTGCCATCACTAAACAGC
  ATGAGGAGAGCCTGATCCGTCTTGACCCACTGCAGCAGCAAGGGCGGAGCAGGTACCTCT
  ACCTCTTCCACACTGGGCAGATCTCCACCCTTCATGAGGTGCTGCTCCATGTAGGAGGCG
  AAGTACCGCAGGATACCCAGCTGAGGCTGCAGGGCCCGGGGCACAGCACCCACGGAGAAG
  GAGAAGTGCTTTGTGCTGGTGGGATTGTAGTGCACAGTCTTTCTGTTGGCCGACAGGGCC
  ATATGTGTGCCATCGTTGAAGACACAGCCACACGGCGCTGGACAGTTGATCCCAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004073
• ORF Size: 1941 bp
• Insert Size: 2200
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_004073.2, NP_004064.2
• RefSeq Size: 2369
• RefSeq ORF: 1941
• Locus ID: 1263
• Domains: pkinase, POLO_box, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015]