PLK3 (NM_004073) Human Untagged Clone

CAT#: SC117577

PLK3 (untagged)-Human polo-like kinase 3 (PLK3)


  "NM_004073" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PLK3
Synonyms CNK; FNK; PLK-3; PRK
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_004073 edited
ATGGAGCCTGCCGCCGGTTTCCTGTCTCCGCGCCCCTTCCAGCGTGCGGCCGCCGCGCCC
GCTCCCCCGGCCGGGCCCGGGCCGCCTCCGAGTGCCTTGCGCGGACCTGAGCTGGAGATG
CTGGCCGGGCTACCGACGTCAGACCCCGGGCGCCTCATCACGGACCCGCGCAGCGGCCGC
ACCTACCTCAAAGGCCGCTTGTTGGGCAAGGGGGGCTTCGCCCGCTGCTACGAGGCCACT
GACACAGAGACTGGCAGCGCCTACGCTGTCAAAGTCATCCCGCAGAGCCGCGTCGCCAAG
CCGCATCAGCGCGAGAAGATCCTAAATGAGATTGAGCTGCACCGAGACCTGCAGCACCGC
CACATCGTGCGTTTTTCGCACCACTTTGAGGACGCTGACAACATCTACATTTTCTTGGAG
CTCTGCAGCCGAAAGTCCCTGGCCCACATCTGGAAGGCCCGGCACACCCTGTTGGAGCCA
GAAGTGCGCTACTACCTGCGGCAGATCCTTTCTGGCCTCAAGTACTTGCACCAGCGCGGC
ATCTTGCACCGGGACCTCAAGTTGGGAAATTTTTTCATCACTGAGAACATGGAACTGAAG
GTGGGGGATTTTGGGCTGGCAGCCCGGTTGGAGCCTCCGGAGCAGAGGAAGAAGACCATC
TGTGGCACCCCCAACTATGTGGCTCCAGAAGTGCTGCTGAGACAGGGCCACGGCCCTGAG
GCGGATGTATGGTCACTGGGCTGTGTCATGTACACGCTGCTCTGCGGGAGCCCTCCCTTT
GAGACGGCTGACCTGAAGGAGACGTACCGCTGCATCAAGCAGGTTCACTACACGCTGCCT
GCCAGCCTCTCACTGCCTGCCCGGCAGCTCCTGGCCGCCATCCTTCGGGCCTCACCCCGA
GACCGCCCCTCTATTGACCAGATCCTGCGCCATGACTTCTTTACCAAGGGCTACACCCCC
GATCGACTCCCTATCAGCAGCTGCGTGACAGTCCCAGACCTGACACCCCCCAACCCAGCT
AGGAGTCTGTTTGCCAAAGTTACCAAGAGCCTCTTTGGCAGAAAGAAGAAGAGTAAGAAT
CATGCCCAGGAGAGGGATGAGGTCTCCGGTTTGGTGAGCGGCCTCATGCGCACATCCGTT
GGCCATCAGGATGCCAGGCCAGAGGCTCCAGCAGCTTCTGGCCCAGCCCCTGTCAGCCTG
GTAGAGACAGCACCTGAAGACAGCTCACCCCGTGGGACACTGGCAAGCAGTGGAGATGGA
TTTGAAGAAGGTCTGACTGTGGCCACAGTAGTGGAGTCAGCCCTTTGTGCTCTGAGAAAT
TGTATAGCCTTCATGCCCCCAGCGGAACAGAACCCGGCCCCCCTGGCCCAGCCAGAGCCT
CTGGTGTGGGTCAGCAAGTGGGTTGACTACTCCAATAAGTTCGGCTTTGGGTATCAACTG
TCCAGCCGCCGTGTGGCTGTGCTCTTCAACGATGGCACACATATGGCCCTGTCGGCCAAC
AGAAAGACTGTGCACTACAATCCCACCAGCACAAAGCACTTCTCCTTCTCCGTGGGTGCT
GTGCCCCGGGCCCTGCAGCCTCAGCTGGGTATCCTGCGGTACTTCGCCTCCTACATGGAG
CAGCACCTCATGAAGGGTGGAGATCTGCCCAGTGTGGAAGAGGTAGAGGTACCTGCTCCG
CCCTTGCTGCTGCAGTGGGTCAAGACGGATCAGGCTCTCCTCATGCTGTTTAGTGATGGC
ACTGTCCAGGTGAACTTCTACGGGGACCACACCAAGCTGATTCTCAGTGGCTGGGAGCCC
CTCCTTGTGACTTTTGTGGCCCGAAATCGTAGTGCTTGTACTTACCTCGCTTCCCACCTT
CGGCAGCTGGGCTGCTCTCCAGACCTGCGGCAGCGACTCCGCTATGCTCTGCGCCTGCTC
CGGGACCGCAGCCCAGCCTAG
>OriGene 5' read for NM_004073 unedited
GCAAGAATTTGTAATACGACNACTATAGGGCGGCCGCGAATTCGCACCAGGCAAATCCAG
GCAGCGCCACGCGCGGCCGGGGCCGGGCGGAACCGATAAGCCGGGACCGCGCTGCGACGC
GCCGGCCGCATGGAGCCTGCCGCCGGTTTCCTGTCTCCGCGCCCCTTCCAGCGTGCGGAC
GCCGCGCCCGCTCCCCCGGCCGGGCCCGGGCCGCCTCCGAGTGCCTTGCGCGGACCTGAG
CTGGAGATGCTGGCCGGGCTACCGACGTCAGACCCCGGGCGCCTCATCACGGACCCGCGC
AGCGGCCGCACCTACCTCAAAGGCCGCTTGTTGGGCAAGGGGGGCTTCGCCCGCTGCTAC
GAGGCCACTGACACAGATACTGGCATCGCCTACGCTGTCAAAGTCATCCCGCATAGCCGC
GTCGCCAAGCCGCATCATCGCGAGAAGATCCTAAATGAGATTGAGCTGCACCGAGACCTG
CAGCACCGCCACATCGTGCGTTTTTCGCACCACTTTGAGGACGCTGACAACATCTACATT
TTCTTGGAGCTCTGCAGCCGAAAGTCCCTGGCCCACATCTGGAATGCCCGGCACACCCTG
TTGGAGCCAGAAGTGCGCTACTACCTGCGGCAGATCCTTTCTGGCCTCAAGTACTTGCAC
CAGCGCGGCATCTTGCACCGGGACCTCAAGTTGTGAAATTCTTTCATCACTGAGAACATG
GAACTGAAGGTGGGGGATTNTGAGCTGGCATCCCAGTTGGATCCTTCGGAGCAAAGGATG
AGACCATCTGTGGCACCCACAACTATGTGGCTNCATAAGTGCTGCTGATACATGACCACN
GNCCTAGAGCGGATGTATGGTCACTGGGCTGTGTCATGTACACACTGCTCTAGCGGAGCC
CCTCCCTTGAGACNGCTGACCTGNAGGAGACCTACAGCTGCATCAAGCAGGTTCACTACA
CGCTGNCTGGCANNCTNTACTGNCTGGCAGGNAGNTCTGGNCGCTT
>OriGene 3' read for NM_004073 unedited
TTTCCGCCAATAGCTTGNACCGCGCCGCTTTCTANNGATCGATTTTTTTTTTTTTTTTTT
TTTTTTCCAATTCTGCAAAATTGTTTATTATCCTAGGAGGAGGCCCCCCTGGGGCTCACA
TCCCAATAAATAAGTGTCTGACAATAAATAAAAGTGGTCCATAAATAACGCCCCCTAGCT
GGGAGCTAAGGCTCAGGCTTATCTTGGAGATGGGGTAGGAGCCAGCGAAGACAAGCCGCC
CCCAACTCCAGTAAAGCTGGTCCCTGATTCCCTGGGGGATTCGGCCCAAAGCCCCCAGTG
AGGCACCAAAGGAAGGGGGAAGGCCACAAAGGCAAGGGCCAGAGCCTGACAGGCACAGGC
CTCAGGCCTCAGGGCTTGGGTCCTAGGCTGGGCTGCGGTCCCGGAGCAGGCGCAGAATCA
TAGCGGAGTCGCTGCCGCAGGTCTGGAGAGCAGCCCAGCTGCCGAAGGTGGGAAGCGAGG
TAAGTACAAACACTACGATTTCGGGCCACAAAAGTCACAAGGAGGGGCTCCCAGCCACTG
AGAATCAGCTTGGTGTGGTCCCCGTAGAAGTTCACCTGGACAGTGCCATCACTAAACAGC
ATGAGGAGAGCCTGATCCGTCTTGACCCACTGCAGCAGCAAGGGCGGAGCAGGTACCTCT
ACCTCTTCCACACTGGGCAGATCTCCACCCTTCATGAGGTGCTGCTCCATGTAGGAGGCG
AAGTACCGCAGGATACCCAGCTGAGGCTGCAGGGCCCGGGGCACAGCACCCACGGAGAAG
GAGAAGTGCTTTGTGCTGGTGGGATTGTAGTGCACAGTCTTTCTGTTGGCCGACAGGGCC
ATATGTGTGCCATCGTTGAAGACACAGCCACACGGCGCTGGACAGTTGATCCCAA
Restriction Sites NotI-NotI     
ACCN NM_004073
ORF Size 1941 bp
Insert Size 2200
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_004073.2, NP_004064.2
RefSeq Size 2369
RefSeq ORF 1941
Locus ID 1263
Domains pkinase, POLO_box, TyrKc, S_TKc
Protein Families Druggable Genome, Protein Kinase
Gene Summary The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015]

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