DYRK3 (NM_003582) Human Untagged Clone

CAT#: SC117867

DYRK3 (untagged)-Human dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (DYRK3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DYRK3
• Synonyms: DYRK5; hYAK3-2; RED; REDK
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_003582 edited
  ATGATGATAGATGAAACCAAATGTCCCCCCTGTTCAAATGTACTCTGCAATCCTTCTGAA
  CCACCTCCACCCAGAAGACTAAATATGACCACTGAGCAGTTTACAGGAGATCATACTCAG
  CACTTTTTGGATGGAGGTGAGATGAAGGTAGAACAGCTGTTTCAAGAATTTGGCAACAGA
  AAATCCAATACTATTCAGTCAGATGGCATCAGTGACTCTGAAAAATGCTCTCCTACTGTT
  TCTCAGGGTAAAAGTTCAGATTGCTTGAATACAGTAAAATCCAACAGTTCATCCAAGGCA
  CCCAAAGTGGTGCCTCTGACTCCAGAACAAGCCCTGAAGCAATATAAACACCACCTCACT
  GCCTATGAGAAACTGGAAATAATTAATTATCCAGAAATTTACTTTGTAGGTCCAAATGCC
  AAGAAAAGACATGGAGTTATTGGTGGTCCCAATAATGGAGGGTATGATGATGCAGATGGG
  GCCTATATTCATGTACCTCGAGACCATCTAGCTTATCGATATGAGGTGCTGAAAATTATT
  GGCAAGGGGAGTTTTGGGCAGGTGGCCAGGGTCTATGATCACAAACTTCGACAGTACGTG
  GCCCTAAAAATGGTGCGCAATGAGAAGCGCTTTCATCGTCAAGCAGCTGAGGAGATCCGG
  ATTTTGGAGCATCTTAAGAAACAGGATAAAACTGGTAGTATGAACGTTATCCACATGCTG
  GAAAGTTTCACATTCCGGAACCATGTTTGCATGGCCTTTGAATTGCTGAGCATAGACCTT
  TATGAGCTGATTAAAAAAAATAAGTTTCAGGGTTTTAGCGTCCAGTTGGTACGCAAGTTT
  GCCCAGTCCATCTTGCAATCTTTGGATGCCCTCCACAAAAATAAGATTATTCACTGCGAT
  CTGAAGCCAGAAAACATTCTCCTGAAACACCACGGGCGCAGTTCAACCAAGGTCATTGAC
  TTTGGGTCCAGCTGTTTCGAGTACCAGAAGCTCTACACATATATCCAGTCTCGGTTCTAC
  AGAGCTCCAGAAATCATCTTAGGAAGCCGCTACAGCACACCAATTGACATATGGAGTTTT
  GGCTGCATCCTTGCAGAACTTTTAACAGGACAGCCTCTCTTCCCTGGAGAGGATGAAGGA
  GACCAGTTGGCCTGCATGATGGAGCTTCTAGGGATGCCACCACCAAAACTTCTGGAGCAA
  TCCAAACGTGCCAAGTACTTTATTAATTCCAAGGGCATACCCCGCTACTGCTCTGTGACT
  ACCCAGGCAGATGGGAGGGTTGTGCTTGTGGGGGGTCGCTCACGTAGGGGTAAAAAGCGG
  GGTCCCCCAGGCAGCAAAGACTGGGGGACAGCACTGAAAGGGTGTGATGACTACTTGTTT
  ATAGAGTTCTTGAAAAGGTGTCTTCACTGGGACCCCTCTGCCCGCTTGACCCCAGCTCAA
  GCATTAAGACACCCTTGGATTAGCAAGTCTGTCCCCAGACCTCTCACCACCATAGACAAG
  GTGTCAGGGAAACGGGTAGTTAATCCTGCAAGTGCTTTCCAGGGATTGGGTTCTAAGCTG
  CCTCCAGTTGTTGGAATAGCCAATAAGCTTAAAGCTAACTTAATGTCAGAAACCAATGGT
  AGTATACCCCTATGCAGTGTATTGCCAAAACTGATTAGCTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003582 unedited
  NGGGGTTCAAATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAGGCTATG
  ACACCTTCATGATGATAGATGAAACCAAATGTCCCCCCTGTTCAAATGTACTCTGCAATC
  CTTCTGAACCACCTCCACCCAGAAGACTAAATATGACCACTGAGCAGTTTACAGGAGATC
  ATACTCAGCACTTTTTGGATGGAGGTGAGATGAAGGTAGAACAGCTGTTTCAAGAATTTG
  GCAACAGAAAATCCAATACTATTCAGTCAGATGGCATCAGTGACTCTGAAAAATGCTCTC
  CTACTGTTTCTCAGGGTAAAAGTTCAGATTGCTTGAATACAGTAAAATCCAACAGTTCAT
  CCAAGGCACCCAAAGTGGTGCCTCTGACTCCAGAACAAGCCCTGAAGCAATATAAACACC
  ACCTCACTGCCTATGAGAAACTGGAAATAATTAATTATCCAGAAATTTACTTTGTAGGTC
  CAAATGCCAAGAAAAGACATGGAGTTATTGGTGGTCCCAATAATGGAGGGTATGATGATG
  CAGATGGGGCCTATATTCATGTACCTCGAGACCATCTAGCTTATCGATATGAGGTGCTGA
  AAATTATTGGCAAGGGGAGTTTTGGGCAGGTGGCCAGGGTCTATGATCACAAACTTCGAC
  AGTACGTGGCCCTAAAAATGGTGCGCAATGAGAAGCGCTTTCATCGTCAAGCAGCTGAGG
  AGATCCGGATTTTGGAGCATCTTAAGAANACAGGATAAACTGGTAGTATGAACGTTATCC
  ACATGCTGNGAAAGTTCACATTCCGGAACCATGTNTGCATGGCCTTTGAAATGCTGAGCA
  TAGACCTTTATGAGCTGATTAAAAAAATAAGTTTCAGGGTTNTAGCGTCAGTTGTACGCA
  AGTTTGCCCATTCATCTTGCATCTTTGGATGC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003582
• ORF Size: 1662 bp
• Insert Size: 2050
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003582.1, NP_003573.1
• RefSeq Size: 2141
• RefSeq ORF: 1662
• Locus ID: 8444
• Domains: pkinase
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a), also known as the RED-L isoform.