Hexokinase II (HK2) (NM_000189) Human Untagged Clone

CAT#: SC309063

HK2 (untagged)-Human hexokinase 2 (HK2)


  "NM_000189" in other vectors (6)

Reconstitution Protocol

USD 760.00

In Stock*

Size
    • 10 ug

Product Images

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol HK2
Synonyms HKII; HXK2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_000189 edited
GAAACTCCGGCGCAGGAGTCCCGGGCTGCCGCTGGCAACATCGTGTCACCCAGCTAAGAA
AATCCGCGGGCCCGAGCCACGCGCCTGTGAATCGGAGAGGTCCCACTGCCCGAGTGGAGC
CGGGCTGAGATTCTTCTCAAGTTGAGCCTCAGTGATCCTGTGGCCGAAGTTAGCGCCTTG
ACGTGGGACAACCGGACACGTCGCCAGGACAGAACTGAGGCGCCTTCTAGCAGTTGTGAC
GCCAAAATCACGTCTCCGGAGACCCGCGCCCTCCGCCAGCCGGGCGCACCCTCGCCGGTA
GCCTTCTTTGTGCGCCGTCCGGACTCCCAGCTCCCGGCCCGGCAGCCGAGCCCCAGCACA
AAGCAGTCGGACCGCGCCGCCCGCCTCCCCTCTCGCGTCTCCGCCTCGGTTTCCCAACTC
TGCGCCGTCGGGCCGCGGCAGGATGATTGCCTCGCATCTGCTTGCCTACTTCTTCACGGA
GCTCAACCATGACCAAGTGCAGAAGGTTGACCAGTATCTCTACCACATGCGCCTCTCTGA
TGAGACCCTCTTGGAGATCTCTAAGCGGTTCCGCAAGGAGATGGAGAAAGGGCTTGGAGC
CACCACTCACCCTACTGCAGCAGTGAAGATGCTGCCCACCTTTGTGAGGTCCACTCCAGA
TGGGACAGAACACGGAGAGTTCCTGGCTCTGGATCTTGGAGGGACCAACTTCCGTGTGCT
TTGGGTGAAAGTAACGGACAATGGGCTCCAGAAGGTGGAGATGGAGAATCAGATCTATGC
CATCCCTGAGGACATCATGCGAGGCAGTGGCACCCAGCTGTTTGACCACATTGCCGAATG
CCTGGCTAACTTCATGGATAAGCTACAAATCAAAGACAAGAAGCTCCCACTGGGTTTTAC
CTTCTCGTTCCCCTGCCACCAGACTAAACTAGACGAGAGTTTCCTGGTCTCATGGACCAA
GGGATTCAAGTCCAGTGGAGTGGAAGGCAGAGACGTTGTGGCTCTGATCCGGAAGGCCAT
CCAGAGGAGAGGGGACTTTGATATCGACATTGTGGCTGTGGTGAATGACACAGTTGGGAC
CATGATGACCTGTGGTTATGATGACCACAACTGTGAGATTGGTCTCATTGTGGGCACGGG
CAGCAACGCCTGCTACATGGAAGAGATGCGCCACATCGACATGGTGGAAGGCGATGAGGG
GCGGATGTGTATCAATATGGAGTGGGGGGCCTTCGGGGACGATGGCTCGCTCAACGACAT
TCGCACTGAGTTTGACCAGGAGATTGACATGGGCTCACTGAACCCGGGAAAGCAACTGTT
TGAGAAGATGATCAGTGGGATGTACATGGGGGAGCTGGTGAGGCTTATCCTGGTGAAGAT
GGCCAAGGAGGAGCTGCTCTTTGGGGGGAAGCTCAGCCCAGAGCTTCTCAACACCGGTCG
CTTTGAGACCAAAGACATCTCAGACATTGAAGGGGAGAAGGATGGCATCCGGAAGGCCCG
TGAGGTCCTGATGCGGTTGGGCCTGGACCCGACTCAGGAGGACTGCGTGGCCACTCACCG
GATCTGCCAGATCGTGTCCACACGCTCCGCCAGCCTGTGCGCAGCCACCCTGGCCGCCGT
GCTGCAGCGCATCAAGGAGAACAAAGGCGAGGAGCGGCTGCGCTCTACTATTGGGGTCGA
CGGTTCCGTCTACAAGAAACACCCCCATTTTGCCAAGCGTCTACATAAGACCGTGCGGCG
GCTGGTGCCCGGCTGCGATGTCCGCTTCCTCCGCTCCGAGGATGGCAGTGGCAAAGGTGC
AGCCATGGTGACAGCAGTGGCTTACCGGCTGGCCGATCAACACCGTGCCCGCCAGAAGAC
ATTAGAGCATCTGCAGCTGAGCCATGACCAGCTGCTGGAGGTCAAGAGGAGGATGAAGGT
AGAAATGGAGCGAGGTCTGAGCAAGGAGACTCATGCCAGTGCCCCCGTCAAGATGCTGCC
CACCTACGTGTGTGCTACCCCGGACGGCACAGAGAAAGGGGACTTCTTGGCCTTGGACCT
TGGAGGAACAAATTTCCGGGTCCTGCTGGTCCGTGTTCGGAATGGGAAGTGGGGTGGAGT
GGAGATGCACAACAAGATCTACGCCATCCCGCAGGAGGTCATGCACGGCACCGGGGACGA
GCTCTTTGACCACATTGTCCAGTGCATCGCGGACTTCCTCGAGTACATGGGCATGAAGGG
CGTGTCCCTGCCTCTGGGTTTTACCTTCTCCTTCCCCTGCCAGCAGAACAGCCTGGACGA
GAGCATCCTCCTCAAGTGGACAAAAGGCTTCAAGGCATCTGGCTGCGAGGGCGAGGACGT
GGTGACCCTGCTGAAGGAAGCGATCCACCGGCGAGAGGAGTTTGACCTGGATGTGGTTGC
TGTGGTGAACGACACAGTCGGAACTATGATGACCTGTGGCTTTGAAGACCCTCACTGTGA
AGTTGGCCTCATTGTTGGCACGGGCAGCAATGCCTGCTACATGGAGGAGATGCGCAACGT
GGAACTGGTGGAAGGAGAAGAGGGGCGGATGTGTGTGAACATGGAATGGGGGGCCTTCGG
GGACAATGGATGCCTAGATGACTTCCGCACAGAATTTGATGTGGCTGTGGATGAGCTTTC
ACTCAACCCCGGCAAGCAGAGGTTCGAGAAAATGATCAGTGGAATGTACCTGGGTGAGAT
TGTCCGTAACATTCTCATCGATTTCACCAAGCGTGGACTACTCTTCCGAGGCCGCATCTC
AGAGCGGCTCAAGACAAGGGGCATCTTTGAAACCAAGTTCTTGTCTCAGATTGAGAGTGA
CTGCCTGGCCCTGCTGCAAGTCCGAGCCATCCTGCAACACTTAGGGCTTGAGAGCACCTG
TGACGACAGCATCATTGTTAAGGAGGTGTGCACTGTGGTGGCCCGGCGGGCAGCCCAGCT
CTGTGGCGCAGGCATGGCCGCTGTGGTGGACAGGATACGAGAAAACCGTGGGCTGGACGC
TCTCAAAGTGACAGTGGGTGTGGATGGGACCCTCTACAAGCTACATCCTCACTTTGCCAA
AGTCATGCATGAGACAGTGAAGGACCTGGCTCCGAAATGTGATGTGTCTTTCCTGCAGTC
AGAGGATGGCAGCGGGAAGGGGGCGGCGCTCATCACTGCTGTGGCCTGCCGCATCCGTGA
GGCTGGACAGCGATAGAACCCCTGAAATCGGAAGGGACTTCCTCTTTCTCTCCTTCTTCC
CTGTTTTAAATTATAAGATGTCATCCCCTTGTGTCAGAGACAGACCCCTTGGCTTTTGCT
TGGCAGAGAGGACCCCACTGGACTGGGTTTTGTCTCTGCATCTCATTGTAGAGCTTGGTG
GCTGAGCTTGGCCCTATTAAGATAAATAGAGTTCCAAATAAGGATTTGTTCACATGCATC
ATAACCATTCCCATTGGTTCTCCTAAAACATGAAAATTATCTCCCTTAGTAATCCCCCTT
GCCAAATTCCATGTCCCTGTATAATTCTACAGGATGGGGACACTAATGAAGATACGGTTG
CTTCACCTTGGAGCCTGAACATGACATTTCTAAGTGGGGTGCATCCCCCAGCACTGATGT
TGTTACTGATTCTCCTGTCAGAGATCTGGGAGGTCTCCACTGAGGATGTGAGCCTGATTA
TCCTATAGGCAGACGTGGGGAGGGTGGAGGGGTGACAGTGGAGGAAAATCCATGGATATC
CACGCAGCAGCCCCTCTTTAACCTCATCTACAAGCATTTGCCCTGTGGATTCCAGCATTT
GCCATTCCTGGAATCAAGGAATCCTGAGTCTGGGCAATGAAACCAAAGCCAGGAGTTGAC
GCATCCTGCAGTTGGGCCAGCTGTCGCATCTCAGCGGGGCGCACATGTTATCCACAAGCA
ATGGACCTTTGGGGAAGGGGGAGTTTTTAGTTTGTTTTACAAATTTTTCCTGCAAAAGTG
GAATCACTGTATTTTCATTTTAATTTATATTTGAAATTTTATTTAGTTCTTGAGCATCTG
CTTCTTCATCTTGACATGTAATGAATGGTCAGTTGTACGTAATGTATTTATATGTTAATT
TGTTATGTATATAGATGTGCAAGTCTTGTCAGAATTGGCCTCAGTGTAGTTAAAGGGCAG
AAGGGGAAGATACTGACTAGTCATAGAAATACCTCATTCGCCTGTGGGAAGAGAAGGGAA
GCCTCTTCAGGGTGAGTGAATGGCAAAGCGGTTGCTTCTGGCTCCTCCTTCCCCTGTGGT
CTTGGAAGTGTGTGGAAGGCAGGGACAGAGATGGAGGCCGAGCCAATAGACTGAAGAGAC
CACAGCAATTGGCTCCTCCATCTAGAGATTTTCTTGGCAGTATTCCATGGGATGTTAAGC
AAAGGAAACCAAAGGAATCGTTTCAAATGGACTCATGGCTTAGAAATCTTTATTCTTAGG
GCAGTCAGTAGTATTCTAAAGCTTTCTGACAAGATAAAGGAAGTCACCAAAATTTCTTTT
TTTAAATTGTATCTAATCCTCAACAACAAACCAAAACAGAACAATTAAACAGCCAAATAA
AACCTCAGGGACAACATTTTTGGTGTATTTGAGCCCTCCCAGCAAGTTTCACCTTGGGTT
TGTATTTTAAATGTTTTACAAGAATTGTCCATGTGCTTCCCTAGGCTGAGCTGGCATTGG
TCTGCTGACCTGTTTTTGTGTTTTTCTTTTTTTTATACACAACATTTATTTCAAACTATT
GGGAGGGATGAGAGTGGCTTAAAAACTTCCATCCCTACTTTTCAAGAGTGCAGTTGATTC
TGAATCTGAAAGCCCGCCTCTGTCCTAAAATACAAACAAGCACAGACATTAAACCTGGAT
ACTATATGATAAAGAGGGATGTAACTATTGAATTGGATACAAGGATCAGAATGGAAAGAA
ACTCACGATGAAATTGAACCTGGTTTTTGTATATTTATCAAACTTGTGCTGAGAATAGTG
TCTGATTATACGACTTTTAAGCAAAGTTGGGTGTAATTAGGTGAAAACAGCCCAGGTCCT
CCCGGGAGCACAGAGGGGCTAGGGGCTGGTCCTTCTCGTTTGCTCTAGTCTTGCTTTGCT
GTCTGGTGTAGCTCCTCTGCTGCTCCCATCTGCACTAATTGACCCAAAACGTGGGTATTT
CCTGCTACACAAAAGCCAAAAGGTTTCATGTAGATTTTAGTTCACTAAAGGGTGCCCACA
AAATAGAGATTAATTTTAACTTAAATTTTAAGCTTGAAGATTAGGTACTATCTGTGAAGT
TACACTTTTTTTTTTTTTTTTAAAGGTAGAGATGTGTGTGTGTGTAGGTATTAAAGATGT
GTTGTTGGTTTCCAAAAAGGAACACTGGAAAATAAATTTTGAATGTTTATGTTCTCAGAA
TCAGGTTGACAGTCCCTTGCTGACATGGCTTTGCTTTGTGTAAATACAGTGGATCTCAAT
CTTCGGGGTGTGATGAATAGCGAATCATCTCAAATCCTTGAGCACTCAGTCTAGTGAAGA
TGTTGTCATTATGTACAATACATAACTAGTTTAATTAACTATGTGATGTTAACTATTATT
AATAAATTTTAACATTTTCCAAAATAAAAAAAAAAAAAAAAAA
>OriGene 5' read for NM_000189 unedited
GTTCGGATTTGNTATACGACTTACTATAGGGCGGCCGCAATCTAGAGTCGACAAGCTTGA
TATCGGTACCGGTCCGGAATTCCCGGGATATCGTCGACCCACGCGTCCGGAAACTCCGGC
GCAGGAGTCCCGGGCTGCCGCTGGCAACATCGTGTCACCCAGCTAAGAAAATCCGCGGGC
CCGAGCCACGCGCCTGTGAATCGGAGAGGTCCCACTGCCCGAGTGGAGCCGGGCTGAGAT
TCTTCTCAAGTTGAGCCTCAGTGATCCTGTGGCCGAAGTTAGCGCCTTGACGTGGGACAA
CCGGACACGTCGCCAGGACAGAACTGAGGCGCCTTCTAGCAGTTGTGACGCCAAAATCAC
GTCTCCGGAGACCCGCGCCCTCCGCCAGCCGGGCGCACCCTCGCCGGTAGCCTTCTTTGT
GCGCCGTCCGGACTCCCAGCTCCCGGCCCGGCAGCCGAGCCCCAGCACAAAGCAGTCGGA
CCGCGCCGCCCGCCTCCCCTCTCGCGTCTCCGCCTCGGTTTCCCAACTCTGCGCCGTCGG
GCCGCGGCAGGATGATTGCCTCGCATCTGCTTGCCTACTTCTTCACGGAGCTCAACCATG
ACCAAGTGCAGAAGGTTGACCAGTATCTCTACCACATGCGCCTCTCTGATGAGACCCTCT
TGGAGATCTCTAAGCGGTTCCGCAAGGAGATGGGAGAAAGGGCTTGGAGCCACCACTCAC
CCTACTGCAGCAGTGAAGATGCTGCCCACCTTTGTGAGGTCCACTCCAGATGGGACAGAA
CACGGAGAGTTCCTTGGCTCTGGATCTTGGAGGGACCCACTCCCGTGTGCTTTGGNTGAA
AAGTACGGACAATGGGCTCCAAAAGTGG
Restriction Sites Please inquire     
ACCN NM_000189
Insert Size 5600 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000189.4, NP_000180.2
RefSeq Size 7109 bp
RefSeq ORF 2754 bp
Locus ID 3099
Cytogenetics 2p12
Domains hexokinase
Protein Families Druggable Genome
Protein Pathways Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Insulin signaling pathway, Metabolic pathways, Starch and sucrose metabolism, Type II diabetes mellitus
Gene Summary 'Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]'

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