PEN2 (PSENEN) (NM_172341) Human Untagged Clone

CAT#: SC309217

PSENEN (untagged)-Human presenilin enhancer 2 homolog (C. elegans) (PSENEN)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PSENEN
• Synonyms: ACNINV2; MDS033; MSTP064; PEN-2; PEN2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_172341 edited
  GGCACCCCAGCCGGAGGAAGTGAGCTCTCCTGGGGCGTGGTTGTTCGTGATCCTTGCATC
  TGTTACTTAGGGTCAAGGCTTGGGTCTTGCCCCGCAGACCCTTGGGACGACCCGGCCCCA
  GCGCAGCTATGAACCTGGAGCGAGTGTCCAATGAGGAGAAATTGAACCTGTGCCGGAAGT
  ACTACCTGGGGGGGTTTGCTTTCCTGCCTTTTCTCTGGTTGGTCAACATCTTCTGGTTCT
  TCCGAGAGGCCTTCCTTGTCCCAGCCTACACAGAACAGAGCCAAATCAAAGGCTATGTCT
  GGCGCTCAGCTGTGGGCTTCCTCTTCTGGGTGATAGTGCTCACCTCCTGGATCACCATCT
  TCCAGATCTACCGGCCCCGCTGGGGTGCCCTTGGGGACTACCTCTCCTTCACCATACCCC
  TGGGCACCCCCTGACAACTTCTGCACATACTGGGGCCCTGCTTATTCTCCCAGGACAGGC
  TCCTTAAAGCAGAGGAGCCTGTCCTGGGAGCCCCTTCTCAAACTCCTAAGACTTGTTTTC
  ATGTCCCACGTTCTCTGCTGACATCCCCCAATAAAGGACCCTAACTTTCAAAAAAAAAAA
  AA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018468 unedited
  GTCGACATTGTATACACTCACTATAGGCGGCCGCGAATTCGCACGAGGGGCACCCCAGCC
  GGAGGAAGTGAGCTCTCCTGGGGCGTGGTTGTTCGTGATCCTTGCATCTGTTACTTAGGG
  TCAAGGCTTGGGTCTTGCCCCGCAGACCCTTGGGACGACCCGGCCCCAGCGCAGCTATGA
  ACCTGGAGCGAGTGTCCAATGAGGAGAAATTGAACCTGTGCCGGAAGTACTACCTGGGGG
  GGTTTGCTTTCCTGCCTTTTCTCTGGTTGGTCAACATCTTCTGGTTCTTCCGAGAGGCCT
  TCCTTGTCCCAGCCTACACAGAACAGAGCCAAATCAAAGGCTATGTCTGGCGCTCAGCTG
  TGGGCTTCCTCTTCTGGGTGATAGTGCTCACCTCCTGGATCACCATCTTCCAGATCTACC
  GGCCCCGCTGGGGTGCCCTTGGGGACTACCTCTCCTTCACCATACCCCTGGGCACCCCCT
  GACAACTTCTGCACATACTGGGGCCCTGCTTATTCTCCCAGGACAGGCTCCTTAAAGCAG
  AGGAGCCTGTCCTGGGAGCCCCTTCTCAAACTCCTAAGACTTGTTTTCATGTCCCACGTT
  CTCTGCTGACATCCCCCAATAAAGGACCCTACTTTTCAAACAACTACCGCCCCCCCCCAC
  ACACACCAAAAACAAAACTCGCTTCTAAATTGCGGCCGGGGTCATAGTTGTTTCCTGGAC
  AAATCCCGGGTGGCATCCCTGGGCCCCCTCCCCAATGCCTCTCTTGGCCCTGAAAGATGC
  CACTTCAATGCCCACCAGCCTTGCCCTAAAAAATACAGTGCTCCTTCTGCTTGACTAGGT
  GGCCTTCTTAATATAAGGGGGGAGGGGGGGGGTTTGCACCCAGGCGCAATTGGTAAAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_018468 unedited
  GACCGCGGGCCGCAATCTANNATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTGAAAGTTAGGGGCCTTTATTGGGGGATGTCAGCAAAAAACGTGGGACATGA
  AAACAAGTCTTAAGAGTTTGAAAAGGGGCTCCCAGGACAGGCTCCTTTGTTTTAAGGAGC
  CTGTCCTGGGAAAATAAACAGGGCCCCAATATGTGCAAAAATTGTCAGGGGGTGCCCAGG
  GGTATGGTGAAGGAAAGGTAATCCCCAAGGGCACCCCAACGGGGCCGGTAAATCTGGAAA
  ATGGGGATCCAGGAGGGGAGCACTATCACCCAAAAGAGGAAGCCCACAGCTGAGCGCCAA
  ACATAACCTTTGATTTGGCTCTGTTCTGGGTAGGCTGGGACAAGGAAGGCCTCTCGGAAG
  AACCAGAAGATGTTGACCAACCAGAGAAAAGGCAGGAAAGCAAACCCCCCCAGGTAGTAC
  TTCCGGCACAGGTTCAATTTCTCCTCATTGGACACTCGCTCCAGGTTCATAACTGCGCTG
  GGGCCGGGTCGTCCCAAGGGTCTGCGGGGCAAGACCCAAGCCTTGACCCTAAGTAACAGA
  TGCAAGGATCACGAACAACCACGCCCCAGGAGAGCTCACTTCCTCCGGCTGGGGTGCCCC
  TTGTGCCGAATTCGCGGCCGCCCTATAGTGAGTCGTATTACAAAATTCTGACGGTTCACT
  AAACGAGCTCTGCTTATATAGACTTCCACCGTACACGCCTACCGGCCATTTGCGTAACGG
  GGGCGGGGTTATACCACATTTTGGAAAGTCCCGNNTGTTTTTGGTGCCAAACCAACTCCC
  ATGACGTCATGGGGGTGGAGACTTGTAATCCCCGTGGTTAAACCGCTTCCACCCCTTTGG
  TGTACTGGCAAACCGATTCCATGTATTACCGAGACTATCCCTAAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_172341
• ORF Size: 306 bp
• Insert Size: 600
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_172341.1.

Reference Data

• RefSeq: NM_172341.1, NP_758844.1
• RefSeq Size: 678
• RefSeq ORF: 306
• Locus ID: 55851
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease, Notch signaling pathway
• Gene Summary: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.