PEN2 (PSENEN) (NM_172341) Human Untagged Clone

CAT#: SC320900

PSENEN (untagged)-Human presenilin enhancer 2 homolog (C. elegans) (PSENEN)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PSENEN
• Synonyms: ACNINV2; MDS033; MSTP064; PEN-2; PEN2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_172341.1 AGGGAAACCTGGGGCGTCTCGCGCAAACGTCCATAACTGAAAGTAGCTAAGGCACCCCTG
  CCGGAGGAAGTGAGCTCTCCTGGGTCAAGGCTTGGGTCTTGCCCCGCAGACCCTTGGGAC
  GACCCGGCCCCAGCGCAGCTATGAACCTGGAGCGAGTGTCCAATGAGGAGAAATTGAACC
  TGTGCCGGAAGTACTACCTGGGGGGGTTTGCTTTCCTGCCTTTTCTCTGGTTGGTCAACA
  TCTTCTGGTTCTTCCGAGAGGCCTTCCTTGTCCCAGCCTACACAGAACAGAGCCAAATCA
  AAGGCTATGTCTGGCGCTCAGCTGTGGGCTTCCTCTTCTGGGTGATAGTGCTCACCTCCT
  GGATCACCATCTTCCAGATCTACCGGCCCCGCTGGGGTGCCCTTGGGGACTACCTCTCCT
  TCACCATACCCCTGGGCACCCCCTGACAACTTCTGCACATACTGGGGCCCTGCTTATTCT
  CCCAGGACAGGCTCCTTAAAGCAGAGGAGCCTGTCCTGGGAGCCCCTTCTCAAACTCCTA
  AGACTTGTTTTCATGTCCCACGTTCTCTGCTGACATCCCCCAATAAAGGACCCTAACTTT
  CGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_172341.1 unedited
  GCCATTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCCATTACGGCCGGGGAGGGA
  AACCTGGGGCGTCTCGCGCAAACGTCCATAACTGAAAGTAGCTAAGGCACCCCTGCCGGA
  GGAAGTGAGCTCTCCTGGGTCAAGGCTTGGGTCTTGCCCCGCAGACCCTTGGGACGACCC
  GGCCCCAGCGCAGCTATGAACCTGGAGCGAGTGTCCAATGAGGAGAAATTGAACCTGTGC
  CGGAAGTACTACCTGGGGGGGTTTGCTTTCCTGCCTTTTCTCTGGTTGGTCAACATCTTC
  TGGTTCTTCCGAGAGGCCTTCCTTGTCCCAGCCTACACAGAACAGAGCCAAATCAAAGGC
  TATGTCTGGCGCTCAGCTGTGGGCTTCCTCTTCTGGGTGATAGTGCTCACCTCCTGGATC
  ACCATCTTCCAGATCTACCGGCCCCGCTGGGGTGCCCTTGGGGACTACCTCTCCTTCACC
  ATACCCCTGGGCACCCCCTGACAACTTCTGCACATACTGGGGCCCTGCTTATTCTCCCAG
  GACAGGCTCCTTAAAGCAGAGGAGCCTGTCCTGGGAGCCCCTTCTCAAACTCCTAAAACT
  TGTTTTCATGTCCCACGTTCTCTGCTGACATCCCCCATAACGACCCTAACTTTCGAAAAA
  CCAAAAACAAAAAAAAAAAAAAAACATGTCGGCCGCCTCGGCCCTCGAGTTTAGACTGAC
  CGTCCGCCGTCATAGCTGTTTCCTGAACAGATCCGGGTGGCATCCGTGTGACCGCTTCCA
  TTGCTTACTGCCTGTAGGTGCGCAGTCCAGTGCCCACAGCTGCTATAATAGTGCATAATT
  GTAGACATAGTGCCTACTAGATATACGGACGTAGAGAGCGAGGCGGAGGGCGA
• Restriction Sites: Please inquire
• ACCN: NM_172341
• ORF Size: 306 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_172341.1, NP_758844.1
• RefSeq Size: 678
• RefSeq ORF: 306
• Locus ID: 55851
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease, Notch signaling pathway
• Gene Summary: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.