RYK (NM_002958) Human Untagged Clone

CAT#: SC310220

RYK (untagged)-Human RYK receptor-like tyrosine kinase (RYK), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RYK
• Synonyms: D3S3195; JTK5; JTK5A; RYK1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002958 edited
  GCGCGTCCCGCGGGCAGCCCCCAACTCCGGACGATGCAGCGAGGAGGCGGCGGCGGCGGC
  GCGCTCCGGAGGTCTGAAGCCACTGCTGGCTGCCACGGGCCGGCGGTGCGATGAGCTGGG
  CAGCCGCCCCCGGCTCGGGGCTGTGAGCGGCTCGGGGCCGGGGGTGGGCGGCGGTGCGGC
  GGGCGGCCGACGCTCCTCTTCGGCGGCGGCGGCGGCGGCCATGCGTGGGGCGGCGCGGCT
  GGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCCCGCGGCCTGAGGGCCCCGCCGCCGCC
  GCCGCTGCTGCTTCTGCTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGC
  CCCCGCCCCGCGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCCAGCGTGAGTCTCTA
  CCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTCTTGATGCAGAACTTTATTATGTGAG
  AAATGACCTTATTAGTCACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAA
  TTTCCTGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAGCTGGGATTCCAAGT
  GGACAATGTTTTGGCAATGGATATGCCCCAGGTCAACATTTCTGTTCAGGGGGAAGTTCC
  ACGCACTTTATCAGTGTTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGT
  TATGATACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAATTTTACCGTCTTAAA
  TTTTAAACGAAGGAAAATGTGCTACAAAAAACTTGAAGAAGTAAAAACTTCAGCCTTGGA
  CAAAAACACTAGCAGAACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCG
  TGTGTTTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTCGTAGCAATAATATT
  AGCTGTTTTGCACCTTCATAGTATGAAAAGGATTGAACTGGATGACAGCATTAGTGCCAG
  CAGTAGTTCCCAAGGGCTGTCTCAGCCATCCACCCAGACGACTCAGTATCTGAGAGCAGA
  CACGCCCAACAATGCAACTCCTATCACCAGTTATCCTACCTTGCGGATAGAGAAGAACGA
  CTTGAGAAGTGTCACTCTTTTGGAGGCCAAAGGCAAGGTGAAGGATATAGCAATATCCAG
  AGAGAGGATAACTCTAAAAGATGTACTCCAAGAAGGTACTTTTGGGCGTATTTTCCATGG
  GATTTTAATAGATGAAAAAGATCCAAATAAAGAAAAACAAGCATTTGTCAAAACAGTTAA
  AGATCAAGCTTCTGAAATTCAGGTGACAATGATGCTCACTGAAAGTTGTAAGCTGCGAGG
  TCTTCATCACAGAAATCTTCTTCCTATTACTCATGTGTGTATAGAAGAAGGAGAAAAGCC
  CATGGTGATATTGCCTTACATGAATTGGGGGAATCTTAAATTGTTTTTACGACAGTGCAA
  GTTAGTAGAGGCCAATAATCCACAGGCAATTTCTCAGCAAGACCTGGTACACATGGCTAT
  TCAGATTGCCTGTGGAATGAGCTACCTGGCCAGAAGGGAAGTCATCCACAAAGACCTGGC
  TGCCAGGAACTGTGTCATTGATGACACACTTCAAGTTAAGATCACAGACAATGCCCTCTC
  CAGAGACTTGTTCCCCATGGACTATCACTGTCTGGGGGACAATGAAAACAGGCCAGTTCG
  TTGGATGGCTCTTGAAAGTCTGGTTAATAACGAGTTCTCTAGCGCTAGTGATGTGTGGGC
  CTTTGGAGTGACGCTGTGGGAACTCATGACTCTGGGCCAGACTCCCTACGTGGACATTGA
  CCCCTTCGAGATGGCCGCATACCTGAAAGATGGTTACCGAATAGCCCAGCCAATCAACTG
  TCCTGATGAATTATTTGCTGTGATGGCCTGTTGCTGGGCCTTAGATCCAGAGGAGAGGCC
  CAAGTTTCAGCAGCTGGTACAGTGCCTAACAGAGTTTCATGCAGCCCTGGGGGCCTACGT
  CTGACTCCTCTCCAATCCCACACCATCAGGAAGAAGGTGCCTGTCGGGGCTCACTTGAAG
  CCTGTCAGGGATGCTTTGTATCTAACACAACGCCAACAGAAGCACATTTGTCTTCCAGAA
  CACCGTGCCTTAGAAATGCTTTAGAATCTGAACTTTTTAAGACAGACTTAATAATGTGGC
  ATATTTTCTAGATATCACTTTTATTAGGTTGAACTGAAAGGGTTTTTGTAAATTTTTTGG
  CCAAAATTTTTTAAAACATACTTACTTTGGACTAGGGGTACATTCTTACAAAATAAATAA
  ACAGTTTTTAAAATTGTTTAGACACAGATATTTGGAATTAGCTATCTTAGTGCCAACTGC
  TTTTTATTTTTTTACTTCATCAAGGTGATGTAAGTGACTCACCTTTAAAGTTTTTTTAGT
  GTTATTTTTTATCACTACTCTGGGAAATGGTTTGTCTTCAAGATGCAATACTTTTCTTAG
  TAAAGGAAAAACAGCATAAAAAGATACCTGGTCTGCCTTGTACAAGAAAAGGCAATATTA
  GAGGAAGAAAATTTAAAGAAAAGCTAGAGGAAAAAAAAATTTTTTTAAAAATACTTATTA
  GAAGCAAACTGCCCTTGCATGGAAAACTGTTTATTTTTTTCAGTGAAAAGGAATTCTGCT
  TTCGTGTTTTTGGGAAAGCAGGAACTGAGTTCATTACATCTTTAATTTGGCAGAAATTAG
  CCTTTCTGTGAACCAGATGTGGTTTGGGGCAGATCTGTAGTAAACAATGGTGATTTTATT
  TATTTTTACTCTCTGGAAAAGGAGATAATACAATTCCAGAAAGTGAACTCATATTTCTAA
  GGTTAAGATTCCCTTTTATTGCACCTAGAATAGTGCTATGCACAGAGCGGGTGCTTGAGT
  TGTTGTCGTTTTTTGTTTGTTTTTTAAATGTAAACTGGTAAATTTTGTGCTTATCTTCAA
  GGCTGGCTTAAGTATAAAATTGTTTTTTAAACACTTGAAAAATTAAAGGATTTGTTTTAT
  ATTAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002958 unedited
  GTTACCATTTNGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCGCGTCCCG
  CGGGCAGCCCCCAACTCCGGACGATGCAGCGAGGAGGCGGCGGCGGCGGCGCGCTCCGGA
  GGTCTGAAGCCACTGCTGGCTGCCACGGGCCGGCGGTGCGATGAGCTGGGCAGCCGCCCC
  CGGCTCGGGGCTGTGAGCGGCTCGGGGCCGGGGGTGGGCGGCGGTGCGGCGGGCGGCCGA
  CGCTCCTCTTCGGCGGCGGCGGCGGCGGCCATGCGTGGGGCGGCGCGGCTGGGGCGGCCG
  GGCCGGAGTTGCCTCCCGGGGGCCCGCGGCCTGAGGGCCCCGCCGCCGCCGCCGCTGCTG
  CTTCTGCTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGCCCCCGCCCCG
  CGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCCAGCGTGAGTCTCTACCTGAGCGAT
  GACGATGTGCGCCGGCTGATCGGTCTTGATGCANAACTTTATTATGTGAGAAATGACCTT
  ATTAATCACTATGCTCTATCCTTTATTCTGTTAATACCCAGTGAGACAAATTTCCTGCAC
  TTCAACTGGCATGCCAAATCTAAGGTTGAATATAAGCTGCGGATTCCAAGTGGACAATGT
  TTTTGGCAATGGATATGCCCCATGTCAACATTTCTTGTTCAGGCCGAATTTTTCCGCACG
  TTTTTACGTGTTTCCGGTTAGAGCCTTTTCTTTTCTGTGACAAGTTCATTTTTAAATTTT
  TAAGCCTAATGGCCAGTTAACTTTTTCCGTTAGATTTTTTACAAGAATTTTTTTTCCCCC
  GTAACAATTTAAAACGAC
  
• Restriction Sites: Please inquire
• ACCN: NM_002958
• ORF Size: 1824 bp
• Insert Size: 3100
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_002958.2, NP_002949.2
• RefSeq Size: 2951
• RefSeq ORF: 1824
• Locus ID: 6259
• Domains: pkinase, TyrKc, S_TKc, WIF
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Gene Summary: The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
  Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).