MTGR1 (CBFA2T2) (NM_001039709) Human Untagged Clone

CAT#: SC310836

CBFA2T2 (untagged)-Human core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (CBFA2T2), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CBFA2T2
• Synonyms: EHT; MTGR1; p85; ZMYND3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001039709, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCAC
  CAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTC
  TCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACATCA
  TCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTC
  TTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCT
  TGCACTGGTGAACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCC
  CTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCG
  CTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCAT
  TGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAG
  AGGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCA
  TCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCC
  TACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCCAAC
  AAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATG
  AGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAA
  TTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGAT
  CGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGT
  TGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAG
  CAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAA
  ATTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAA
  CAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGT
  CATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGCAGT
  GGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCT
  GTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTC
  CTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGT
  TCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001039709
• ORF Size: 1728 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001039709.1, NP_001034798.1
• RefSeq Size: 7449
• RefSeq ORF: 1728
• Locus ID: 9139
• Protein Families: Transcription Factors
• Gene Summary: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (4) lacks an alternate exon compared to variant 2. The resulting isoform (MTGR1a) is shorter at the N-terminus compared to isoform MTGR1b.