TKTL1 (NM_012253) Human Untagged Clone

CAT#: SC318026

TKTL1 (untagged)-Human transketolase-like 1 (TKTL1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TKTL1
• Synonyms: TKR; TKT2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_012253 edited
  TCGTATAGCATACATTATACGAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCG
  TCGAGAGCGGATTCGCTCTTCAGACGCCGGAGACGTAGGAGTGGGTCTTCAGACTCCAAA
  GGGGTTGGACTAATGGCGGATGCTGAGGCGAGGGCTGAGTTCCCGGAGGAGGCCAGACCT
  GACAGGGGCACCTTGCAGGTGTTTCAAGATATGGCCAGCCGCTTGCGAATCCATTCCATC
  AGGGCCACATGCTCCACGAGCTCCGGCCACCCTACATCATGTAGCAGTTCTTCTGAGATC
  ATGTCTGTGCTGTTCTTCTACATCATGAGGTACAAGCAGTCAGATCCAGAGAATCCGGAC
  AACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTC
  GGACAAGGACTGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCC
  AGCTACCGGGTGTTCTGCCTCATGAGTGATGGCGAGTCCTCAGAAGGCTCTGTCTGGGAG
  GCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTGTGGCAACCTTTGATGTGAAC
  CGCCTGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTATCAGAGGCGC
  TGCGAAGCCTTTGGGTGGAACACTTATGTGGTGGACGGCCGGGACGTGGAGGCACTGTGC
  CAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACC
  TTCAAGGGCCGGGGCACCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATG
  CCGAGAGAAAGAGCAGATGCCATTATCAAATTAATTGAGAGCCAGATACAGACCAGCAGG
  AATCTTGACCCACAGCCCCCCATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGG
  ATGACCTCTCCACCTGATTACAGAGTTGGTGACAAGATAGCTACTCGGAAAGCATGCGGT
  CTGGCTCTGGCTAAGCTGGGCTACGCGAACAACAGAGTCGTTGTGCTGGATGGTGACACC
  AGGTACTCTACTTTCTCTGAGATATTCAACAAGGAGTACCCTGAGCGCTTCATCGAGTGC
  TTTATGGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACC
  ATTGCTTTTGCTAGCACCTTTGCTGCCTTTCTGACTCGAGCATTTGATCACATCCGGATA
  GGAGGCCTCGCTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGT
  GACGATGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTCCGAACCATTCCCAAG
  TGCACGATCTTCTACCCAACTGATGCCGTCTCCACGGAGCATGCTGTTGCTCTGGCAGCC
  AATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAGAAACTATGGTTATTTACACC
  CCACAAGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGTCAGTGACAAG
  GTCACAGTTATTGGAGCTGGAATTACTGTGTATGAAGCCTTAGCAGCTGCTGATGAGCTT
  TCGAAACAAGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTC
  GCCACCATCGTCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCAC
  TACCCGCAAGGTGGCATCGGGGAAGCTGTCTGCGCAGCCGTCTCCATGGATCCTGACATT
  CAGGTTCATTCGCTGGCAGTGTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGCTG
  GATATGTATGGAATTAGTGCCAGACATATCATAGTGGCCGTGAAATGCATGTTGCTGAAC
  TAAAATAGCTGTTAGCTTTGGTCTTTTGGCCTCTTTACCCTGTGTTTATGTTTGTTCCAA
  AACCATCATTTAAATCTCTACTGTCACATTTTGTTTCTTAAAAGCAAAGCCAGCTAACAC
  CTTCATTCATCCCTAGTTCGGAAATTCAAGCTAACTACTTACCCTTTAAACTGTCACTGC
  ATATGCAAGTACCGCTCTAATTTTTGGATCATTAAGGGGAGTTACACAACTTTTAAGTGA
  AAAAAATAGGTAACAAAACAACCACCTGATAGTAAGTTTTCTGATAAGACTATAGATAAG
  TGGTAGAGGTAATCAATTCTTCCGAAGTGTTTCCTTCGTGAATAACTGGTAGAGGTAATA
  GTTTTTTCAATGTATTTCCTTCATGAGTAAAGAAAATGTGGATTGAAGTATAGATTCCAG
  TAGCCTAGTTTCCACAGCACGATAACACCATGACGCCTACTGCTGTTCCCACCTTGGGAT
  TCTGTGTGCTGCCATCCCACCTGCAGCTGCCCTGGAATTCCCTTCGCTGTTTGCCTTCAT
  CTCCCTCCACGTTTGAGAGGCTGTCAGGCAGCAGCGAAAGCTTGTTAGGATGTCCTGTGC
  TGCTTGTGATGAGAGCCTCCACACTGTACTGTTCAAGTCAATGTTAATAAAGCATTTCAA
  AACCAAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_012253
• ORF Size: 1791 bp
• Insert Size: 2600
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The ORF of this clone has been fully sequenced and found to contain one SNP compared with NM_012253.2.

Reference Data

• RefSeq: NM_012253.2, NP_036385.2
• RefSeq Size: 2530
• RefSeq ORF: 1791
• Locus ID: 8277
• Domains: transketolase, transket_pyr, transketolase_C
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Pentose phosphate pathway
• Gene Summary: The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).