Karyopherin beta 3 (IPO5) (NM_002271) Human Untagged Clone

CAT#: SC318500

IPO5 (untagged)-Human importin 5 (IPO5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IPO5
• Synonyms: IMB3; imp5; KPNB3; Pse1; RANBP5
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_002271, the custom clone sequence may differ by one or more nucleotides
  ATGCCTGAGGATCAAGTTGGAAAACTAGAAGCAACAGAAAACACAATAAGCGCAATGGCG
  GCGGCCGCGGCGGAGCAGCAACAGTTCTACCTGCTCCTGGGAAACCTGCTCAGCCCCGAC
  AATGTGGTCCGGAAACAGGCAGAGGAAACCTATGAGAATATCCCAGGCCAGTCAAAGATC
  ACATTCCTCTTACAAGCCATCAGAAATACAACAGCTGCTGAAGAGGCTAGACAAATGGCC
  GCCGTTCTCCTAAGACGTCTCTTGTCCTCTGCATTTGATGAAGTCTATCCAGCACTTCCC
  TCTGATGTTCAGACTGCCATCAAGAGTGAGCTACTCATGATTATTCAGATGGAAACACAA
  TCTAGCATGAGGAAAAAAGTTTGTGATATTGCGGCAGAACTGGCCAGGAATTTAATAGAT
  GAGGATGGCAATAACCAGTGGCCCGAAGGTTTGAAGTTCCTTTTTGATTCAGTCAGCTCT
  CAAAATGTGGGACTGCGGGAAGCTGCCCTTCACATTTTCTGGAACTTTCCTGGAATTTTT
  GGGAACCAGCAACAACACTATTTAGATGTCATCAAACGAATGTTAGTTCAGTGTATGCAA
  GATCAGGAACACCCGTCGATCAGGACGTTATCTGCTAGAGCTACAGCTGCATTTATACTT
  GCAAATGAGCATAATGTTGCTCTGTTCAAACATTTTGCAGACTTGCTACCGGGATTCCTA
  CAGGCGGTAAATGACTCGTGCTACCAGAATGATGATTCTGTCCTAAAATCCCTCGTTGAG
  ATTGCAGATACTGTTCCAAAGTATTTGCGTCCTCACTTGGAAGCAACTCTACAGCTAAGT
  CTAAAGTTGTGTGGAGACACTAGCCTCAACAATATGCAACGCCAGCTTGCCCTTGAAGTG
  ATCGTCACCCTCTCTGAGACTGCAGCTGCTATGTTAAGAAAACATACCAATATTGTTGCA
  CAGACTATTCCTCAGATGTTAGCAATGATGGTTGATTTGGAAGAAGATGAGGACTGGGCA
  AATGCAGATGAACTAGAAGATGATGATTTTGACAGCAATGCAGTTGCAGGCGAGAGTGCT
  CTAGATCGAATGGCTTGCGGACTTGGTGGAAAGCTCGTTCTGCCGATGATCAAGGAACAC
  ATTATGCAAATGCTTCAAAATCCTGACTGGAAATACCGGCATGCAGGATTGATGGCCTTA
  TCTGCCATTGGTGAAGGGTGCCACCAGCAAATGGAAGGAATTCTAAATGAGATCGTAAAT
  TTTGTTTTACTTTTTCTCCAGGATCCTCATCCAAGAGTAAGGTATGCAGCCTGTAATGCC
  GTGGGACAGATGGCTACAGATTTTGCACCTGGTTTCCAAAAGAAATTTCATGAGAAGGTG
  ATTGCAGCTCTGCTGCAGACCATGGAAGACCAAGGCAATCAACGTGTGCAGGCCCATGCA
  GCTGCTGCCCTCATTAACTTTACTGAAGACTGTCCCAAGTCACTACTTATTCCATACTTG
  GATAATTTGGTGAAACATCTGCATTCCATTATGGTACTGAAGCTTCAAGAGCTGATTCAG
  AAAGGCACCAAGTTAGTTTTGGAACAAGTTGTGACATCCATTGCATCAGTTGCCGATACT
  GCAGAAGAAAAATTTGTCCCCTACTATGATTTATTTATGCCATCACTGAAGCACATCGTT
  GAGAATGCGGTTCAAAAAGAACTGAGACTTCTGAGAGGAAAAACTATTGAATGCATTAGC
  CTCATTGGTCTGGCTGTTGGGAAGGAAAAATTCATGCAGGATGCATCAGATGTGATGCAG
  CTTTTGTTAAAGACCCAGACAGACTTCAATGATATGGAAGATGATGATCCTCAGATCTCT
  TACATGATCTCAGCATGGGCCAGAATGTGCAAAATCCTTGGAAAAGAATTTCAGCAATAC
  CTTCCAGTGGTTATGGGGCCTTTAATGAAGACGGCTTCAATTAAGCCCGAAGTAGCCCTT
  TTAGATACCCAAGACATGGAGAATATGAGTGATGATGATGGTTGGGAATTTGTGAACCTT
  GGAGATCAGCAAAGCTTTGGTATTAAAACTGCAGGACTAGAAGAAAAATCAACTGCTTGC
  CAGATGTTGGTTTGCTATGCTAAGGAGTTAAAGGAAGGCTTTGTGGAGTACACCGAACAG
  GTTGTCAAACTGATGGTCCCTTTACTGAAATTTTATTTCCACGATGGTGTTCGAGTGGCA
  GCAGCGGAATCCATGCCTCTTCTCCTGGAGTGTGCAAGAGTCCGTGGTCCTGAGTATCTC
  ACACAGATGTGGCATTTTATGTGTGATGCTCTAATTAAGGCCATTGGTACAGAACCAGAT
  TCAGACGTCCTCTCAGAAATAATGCATTCTTTTGCAAAGTGCATTGAAGTAATGGGAGAT
  GGATGCCTTAATAATGAACACTTTGAAGAACTGGGAGGTATATTGAAAGCAAAGCTTGAA
  GAACATTTTAAAAATCAAGAATTACGACAAGTTAAAAGACAAGATGAAGACTATGATGAA
  CAGGTCGAAGAGTCACTACAAGATGAGGATGATAATGATGTTTATATTCTGACCAAAGTG
  TCAGATATTTTACACTCAATATTCAGTAGCTACAAAGAAAAGGTGTTACCATGGTTTGAA
  CAGCTGCTTCCATTAATTGTCAACCTCATTTGTCCACATAGACCATGGCCAGACAGACAA
  TGGGGATTATGCATCTTTGATGATGTCATAGAACACTGTAGTCCAGCCTCATTTAAATAC
  GCAGAATATTTCTTAAGACCAATGCTCCAATATGTATGTGACAACAGCCCAGAAGTCAGG
  CAAGCAGCTGCATATGGCCTGGGAGTCATGGCACAGTACGGTGGAGATAATTATCGCCCT
  TTTTGTACAGAAGCACTTCCCCTGCTGGTAAGAGTTATTCAGTCTGCGGATTCTAAGACC
  AAAGAAAATGTCAATGCTACAGAGAACTGCATCTCAGCAGTAGGGAAAATCATGAAGTTC
  AAGCCTGACTGTGTAAACGTTGAAGAGGTCCTTCCACACTGGTTGTCTTGGCTTCCACTA
  CATGAAGATAAAGAAGAAGCTGTTCAGACTTTCAATTATCTGTGTGACCTGATTGAAAGT
  AATCATCCAATTGTTCTTGGCCCAAACAATACCAATCTGCCCAAAATATTTAGTATAATT
  GCGGAAGGAGAAATGCACGAGGCAATTAAACATGAAGATCCTTGTGCCAAACGTCTGGCC
  AATGTCGTTCGCCAAGTACAGACTTCTGGAGGACTGTGGACTGAGTGCATAGCACAGCTC
  AGTCCTGAGCAGCAGGCCGCCATTCAGGAGCTCCTGAACTCTGCG
  
• Restriction Sites: Please inquire
• ACCN: NM_002271
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002271.4, NP_002262.3
• RefSeq Size: 6019 bp
• RefSeq ORF: 3348 bp
• Locus ID: 3843
• Cytogenetics: 13q32.2
• Protein Families: Druggable Genome
• Gene Summary: 'Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]'