PPM1F (NM_014634) Human Untagged Clone

CAT#: SC320526

PPM1F (untagged)-Human protein phosphatase, Mg2+/Mn2+ dependent, 1F (PPM1F)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PPM1F
• Synonyms: CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014634.2 GAGGAGACAGCTGAGGCCCGCGGAGACCAGGGGGTGAAGCCTGGAGACCCTCTTGCCCTG
  GCCTAGCTGCAGGCCCCCGGGATGCTTTGGGCATGTCCTCTGGAGCCCCACAGAAGAGCA
  GCCCAATGGCCAGTGGAGCTGAGGAGACCCCAGGCTTCCTGGACACGCTCCTGCAAGACT
  TCCCAGCCCTGCTGAACCCAGAGGACCCTCTGCCATGGAAGGCCCCAGGGACGGTGCTCA
  GCCAGGAGGAGGTGGAGGGCGAGCTGGCTGAGCTGGCCATGGGCTTTCTGGGCAGCAGGA
  AGGCCCCGCCACCACTTGCTGCTGCTCTGGCCCACGAAGCAGTTTCACAGCTGCTACAGA
  CAGACCTTTCCGAATTCAGGAAGTTGCCCAGGGAGGAAGAAGAAGAGGAGGAGGACGATG
  ACGAGGAAAAGGCCCCTGTGACCTTGCTGGATGCCCAAAGCCTGGCACAGAGTTTCTTTA
  ACCGCCTTTGGGAAGTCGCCGGCCAGTGGCAGAAGCAGGTGCCATTGGCTGCCCGGGCCT
  CACAGCGGCAGTGGCTGGTCTCCATCCACGCCATCCGGAACACTCGCCGCAAGATGGAGG
  ACCGGCACGTGTCCCTCCCTTCCTTCAACCAGCTCTTCGGCTTGTCTGACCCTGTGAACC
  GCGCCTACTTTGCTGTGTTTGATGGTCACGGAGGCGTGGATGCTGCGAGGTACGCCGCTG
  TCCACGTGCACACCAACGCTGCCCGCCAGCCAGAGCTGCCCACAGACCCTGAGGGAGCCC
  TCAGAGAAGCCTTCCGGCGCACCGACCAGATGTTTCTCAGGAAAGCCAAGCGAGAGCGGC
  TGCAGAGCGGCACCACAGGTGTGTGTGCGCTCATTGCAGGAGCGACCCTGCACGTCGCCT
  GGCTCGGGGATTCCCAGGTCATTTTGGTACAGCAGGGACAGGTGGTGAAGCTGATGGAGC
  CACACAGACCAGAACGGCAGGATGAGAAGGCGCGCATTGAAGCATTGGGTGGCTTTGTGT
  CTCACATGGACTGCTGGAGAGTCAACGGGACCCTGGCCGTCTCCAGAGCCATCGGGGATG
  TCTTCCAGAAGCCCTACGTGTCTGGGGAGGCCGATGCAGCTTCCCGGGCGCTGACGGGCT
  CCGAGGACTACCTGCTGCTTGCCTGTGATGGCTTCTTTGACGTCGTACCCCACCAGGAAG
  TTGTTGGCCTGGTCCAGAGCCACCTGACCAGGCAGCAGGGCAGCGGGCTCCGTGTCGCCG
  AGGAGCTGGTGGCTGCGGCCCGGGAGCGGGGCTCCCACGACAACATCACGGTCATGGTGG
  TCTTCCTCAGGGACCCCCAAGAGCTGCTGGAGGGCGGGAACCAGGGAGAAGGGGACCCCC
  AGGCAGAAGGGAGGAGGCAGGACTTGCCCTCCAGCCTTCCAGAACCTGAGACCCAGGCTC
  CACCAAGAAGCTAGGTGGTTTCCAGGCCCCTGCCCTCCCCTTCCTCCCATCCTTGTCCTT
  CTCTCCCTCAGAAGCCTCAGGACCCAACAGGTGGCAGGCAGTGGACAGGGTGCCCGCCCC
  ACAGTGCTTTCCCCAGCACCCCAGAGCCAGTCGGGACACCCCCCGCAGCCCGTCCTGGTG
  GCTGTGGAACTGCACTGGGTGGCGGGCAGATGGTGGAAGGCAGCTTAGGAGACCTCACCA
  AAGAGAAGATGGACCGGCTCTTGCTCCCAGCTCCTATTAGGCCCGGGGTGGGACCAGAGG
  TCATAGGTGCCCAACGGCAGCCAAACCAAAGACACTGGTGTGCATGGGGCAGCATGGTTG
  TGCACGTGGGACCCTGGGGCGGACCCAGGAGCCAAACTCTTGAAGCACCCCCTGGGTCAG
  GCCCAGCAGCGGAGTGGCCAGCCCCAGTTTCCCATTGCTCCTCTCTGCGGCCAGGGCCAG
  GTGGGTTCATATTTACAGATATGCCCAGCCAGTCCTGGTCGGCCACACCAGTGTCCCAAA
  GAGGAGAGCGCAGCAGAGCCAGGGGTCTGTTCTGTAGCAGCCACCCCCCTGCCCCCACTC
  CAGGGCAGCCATGATGTGCTTGGGCCCACCAGGGCCTTCCGGGCTGCTCTCTTCCCTGAG
  CCCGGAACCGGCGACGCACATGTGTCTTTTGTTGGTGTGTTTGTTTTTTTCCAGGGAGGT
  CTAATTCCGAAGCAGTATTCCAGGTTTTCTCTTTGTTTTATCAGTGCCAAGATGACCTGT
  TGTGTCATATAATTTAAGCAGAGCTTAGCATTTATTTTATTCTTTAGAAAACTTAAGTAT
  TTACTTTTTTAAAGCTATTTTTCAAGGAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014634.2 unedited
  GTACAGAGACGATCTGGTGGCTCCCTATGGCCGGTGGAGGAATCGTCGACTGGATCCGGT
  ACCGAGGAGATCTGCCGCCGCGATCGCGGCGCGCCAGATCTCAAGCTTAACTAGTTAGCG
  GACCGACGCGTTAAGCGGCCGCGAATTCAGATCCACAAGTTTGTACAAAAAAGCAGGCTT
  GTAAAACGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAGGCCTGGGTGGCGAATTC
  GGCACGAGGGAGGAGACAGCTGAGGCCCGCGGAGACCAGGGGGTGAAGCCTGGAGACCCT
  CTTGCCCTGGCCTAGCTGCAGGCCCCCGGGATGCTTTGGGCATGTCCTCTGGAGCCCCAC
  AGAAGAGCAGCCCAATGGCCAGTGGAGCTGAGGAGACCCCAGGCTTCCTGGACACGCTCC
  TGCAAGACTTCCCAGCCCTGCTGAACCCAGAGGACCCTCTGCCATGGAAGGCCCCAGGGA
  CGGTGCTCAGCCAGGAGGAGGTGGAGGGCGAGCTGGCTGAGCTGGCCATGGGCTTTCTGG
  GCAGCAGGAAGGCCCCGCCACCACTTGCTGCTGCTCTGGCCCACGAAGCAGTTTCACAGC
  TGCTACAGACAGACCTTTCCGAATTCAGAAGTTGCCCAGGGAGGAAGAAGAGAGGAGGAG
  GACGATGACGAGGAAAAGGCCCCTGTGACCTTGCTGGATGCCCAAAGCCTGGCACAGAGT
  TTCTTTAACCCGCCTTTGGGAAGTCGCCGGCCAGTGGCAGAGCAAGTGCCATTGGCTGCC
  CGGCCCTCACAGCGGCAGTGGCTGGTCTCATCCACGCCATCCGGACACTCGCCGCAAGAT
  GGAGGACCGGCACGTGTCCCTCCTTCTTCAACCAGCTCTTCGGCTTGTCTGACCTGTGAA
  CCGGGCCTAACTTGCTGGTTGATGTCACGGAGGCGTGATGGCTTGGCAAGTACGCCGGCT
  GTTCACACGTTGCCACACCCACACGCTT
• Restriction Sites: Please inquire
• ACCN: NM_014634
• ORF Size: 1365 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_014634.2, NP_055449.1
• RefSeq Size: 5169
• RefSeq ORF: 1365
• Locus ID: 9647
• Domains: PP2C
• Protein Families: Druggable Genome, Phosphatase
• Gene Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]