SELS (SELENOS) (NM_203472) Human Untagged Clone

CAT#: SC321028

VIMP (untagged)-Human selenoprotein S (SELS), transcript variant 1 (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below)

Specifications

Product Data

• Type: Human Untagged Clone
• Symbol: SELENOS
• Synonyms: AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_203472.1 GGGGAGGGCTGGGCGGCGGCGGCGGCGGCGGTCATGGAACGCCAAGAGGAGTCTCTGTCC
  GCGCGGCCGGCCCTGGAGACCGAGGGGCTGCGCTTCCTGCACACCACGGTGGGCTCCCTG
  CTGGCCACCTATGGCTGGTACATCGTCTTCAGCTGCATCCTTCTCTACGTGGTCTTTCAG
  AAGCTTTCCGCCCGGCTAAGAGCCTTGAGGCAGAGGCAGCTGGACCGAGCTGCGGCTGCT
  GTGGAACCTGATGTTGTTGTTAAACGACAAGAAGCTTTAGCAGCTGCTCGACTGAAAATG
  CAAGAAGAACTAAATGCGCAAGTTGAAAAGCATAAGGAAAAACTGAAACAACTTGAAGAA
  GAAAAAAGGAGACAGAAGATTGAAATGTGGGACAGCATGCAAGAAGGAAAAAGTTACAAA
  GGAAATGCAAAGAAGCCCCAGGAGGAAGACAGTCCTGGGCCTTCCACTTCATCTGTCCTG
  AAACGGAAATCGGACAGAAAGCCTTTGCGGGGAGGAGGTTATAACCCGTTGTCTGGTGAA
  GGAGGCGGAGCTTGCTCCTGGAGACCTGGACGCAGAGGCCCGTCATCTGGCGGATGAGGC
  TAAGAATCTTGTAGAATATTCCGTGGTTGCTTCTTGACCAAGGGAAATACAGTCTGGCTG
  TGAGAGACTTAAAATCTCTTGAGGAGCGCTCTGGAGAATGGCTGAAGGAGAGGAAACAGG
  AGCCTTGAGCAGTGTAATTACAAACAAATAGGTTGGCATAGTCTTAAGTCTTTGAGTCTA
  GAGAGATTTGAGTTTTGTTTTGCCTGTGGAGGCAATTGGGGGTTTCAGGTCAAAGAGAGG
  GTCAGTGGAAACAAGGGTGGGCCTTGTGAGGTGTGGGGAAGCCCTGGGACCCTCACTCCC
  CTTCCAGTGTGTAACTGGATTGGCTCCCACCAGCCCAGAAGATTTACGACGTGGGAAATG
  GTATACTTGGATTAAAATATTTCATCCAGATTTGTTTACATCTAGAGAGAACCCCTTGTA
  GGTTATAAGGAAACTTTTTAACATTCTTCCTTGAATATATTTTCTGTAGCTGAAAATGTT
  TGTGAAGTGGCTGTCAACTACACATCGCATGAGTAGAGGGGCTCTGGGTCGGGGTTTCAT
  ATGCAGCAGAGCAGCTCCCTTGCTGCCGTCCATCAAGAGCCCTCAACACAAGAGTTTGTT
  ATAAATAGAAATAAACGACAAAAAGTAGAGGGGTAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_203472.1 unedited
  TCGATTTGTATACGACTCCTATAGGGCGGCCGGCAAATTCGGCCATTACGGCCGGGGAGG
  GCTGGGCGGCGGCGGCGGCGGCGGTCATGGAACGCCAAGAGGAGTCTCTGTCCGCGCGGC
  CGGCCCTGGAGACCGAGGGGCTGCGCTTCCTGCACACCACGGTGGGCTCCCTGCTGGCCA
  CCTATGGCTGGTACATCGTCTTCAGCTGCATCCTTCTCTACGTGGTCTTTCAGAAGCTTT
  CCGCCCGGCTAAGAGCCTTGAGGCAGAGGCAGCTGGACCGAGCTGCGGCTGCTGTGGAAC
  CTGATGTTGTTGTTAAACGACAAGAAGCTTTAGCAGCTGCTCGACTGAAAATGCAAGAAG
  AACTAAATGCGCAAGTTGAAAAGCATAAGGAAAAACTGAAACAACTTGAAGAAGAAAAAA
  GGAGACAGAAGATTGAAATGTGGGACAGCATGCAAGAAGGAAAAAGTTACAAAGGAAATG
  CAAAGAAGCCCCAGGAGGAAGACAGTCCTGGGCCTTCCACTTCATCTGTCCTGAAACGGA
  AATCGGACAGAAAGCCTTTGCGGGGAGGAGGTTATAACCCGTTGTCTGGTGAAGGAGGCG
  GAGCTTGCTCCTGGAGACCTGGACGCAGAGGCCCGTCATCTGGCGGATGAGGCTAAGAAT
  CTTGTAGAATATTCCGTGGTTGCTTCTTGACCAAGGGAAATACAGTCTGGCTGTGAGAGA
  CTTAAAATCTCTTGAGGAGCGCTCTGGAGAATGGCTGAGGAGAGGAAACAGGAGCCCTTG
  AGCAGTGTAATTACAAACAAAATAGGTTTGCATAGTCTTAGTCTTTGAGTCTAGAGAGAT
  TTGAGTTTTTGTTTTGCCTGTGAGGCATTGGGGGTTCAGTCAAAGAGAGGTCAGTGCAAA
  CAAGGTGGACTTGTGAGGTGTGGGGAAGCCTGGACCTAATTCCCCCT
• Restriction Sites: Please inquire
• ACCN: NM_203472
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). The expression of this clone is not guaranteed due to the nature of selenoproteins.
• OTI Annotation: This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins.

Reference Data

• RefSeq: NM_203472.1, NP_982298.1
• RefSeq Size: 1292
• Locus ID: 55829
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
  Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and lacks a selenocysteine (Sec) insertion sequence (SECIS) element in its 3' UTR, which is necessary for the recognition of UGA as a Sec codon. This results in translation termination at the UGA codon and a non-Sec containing shorter isoform (2) compared to isoform 1 (PMID:23614019).