emopamil binding protein (EBP) (NM_006579) Human Untagged Clone

CAT#: SC322500

EBP (untagged)-Human emopamil binding protein (sterol isomerase) (EBP)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: EBP
• Synonyms: CDPX2; CHO2; CPX; CPXD; MEND
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322500 GCGAGACCCAGCCTAAAGAGAGCCCGGAGCCAGCGTGGGAGGCCGCTGCCGTCGCGCGCC
  TTGGTTTTTCTGTTCCTTTTTTTTTTTTTTTTTTTAACTTCCTGCCTATACACACGCAGC
  CATCAGCCCACAAAGACATGACTACCAACGCGGGCCCCTTGCACCCATACTGGCCTCAGC
  ACCTAAGACTGGACAACTTTGTACCTAATGACCGCCCCACCTGGCATATACTGGCTGGCC
  TCTTCTCTGTCACAGGGGTCTTAGTCGTGACCACATGGCTGTTGTCAGGTCGTGCTGCGG
  TTGTCCCATTGGGGACTTGGCGGCGACTGTCCCTGTGCTGGTTTGCAGTGTGTGGGTTCA
  TTCACCTGGTGATCGAGGGCTGGTTCGTTCTCTACTACGAAGACCTGCTTGGAGACCAAG
  CCTTCTTATCTCAACTCTGGAAAGAGTATGCCAAGGGAGACAGCCGATACATCCTGGGTG
  ACAACTTCACAGTGTGCATGGAAACCATCACAGCTTGCCTGTGGGGACCACTCAGCCTGT
  GGGTGGTGATCGCCTTTCTCCGCCAGCATCCCCTCCGCTTCATTCTACAGCTTGTGGTCT
  CTGTGGGCCAGATCTATGGGGATGTGCTCTACTTCCTGACAGAGCACCGCGACGGATTCC
  AGCACGGAGAGCTGGGCCACCCTCTCTACTTCTGGTTTTACTTTGTCTTCATGAATGCCC
  TGTGGCTGGTGCTGCCTGGAGTCCTTGTGCTTGATGCTGTGAAGCACCTCACTCATGCCC
  AGAGCACGCTGGATGCCAAGGCCACAAAAGCCAAGAGCAAGAAGAACTGAGGAGTGGTGG
  ACCAGGCTCGAACACTGGCCGAGGAGGAGCTCTCTGCCTGCCAGAAGAGTCTAGTCCTGC
  TCCCACAGTTTGGAGGGACAAAGCTAATTGATCTGTCACACTCAGGCTCATGGGCAGGCA
  CAAGAAGGGGAATAAAGGGGCTGTGTGAAGGCACTGCTGGGAGCCATTAGAACACAGATA
  CAAGAGAAGCCAGGAGGTCTATGATGGTGACGATTTTTAAAATCAGGAAATAAAAGATCT
  TGACTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC322500 unedited
  TATATTTTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTC
  CGGAATTCCCGGGATATCGTCGACCCACGCGTCCGCCCGGAGCCAGCGTGGGAGGCCGCT
  GCCGTCGCGCGCCTTGGTTTTTCTGTTCCTTTTTTTTTTTTTTTTTTTAACTTCCTGCCT
  ATACACACGCAGCCATCAGCCCACAAAGACATGACTACCAACGCGGGCCCCTTGCACCCA
  TACTGGCCTCAGCACCTAAGACTGGACAACTTTGTACCTAATGACCGCCCCACCTGGCAT
  ATACTGGCTGGCCTCTTCTCTGTCACAGGGGTCTTAGTCGTGACCACATGGCTGTTGTCA
  GGTCGTGCTGCGGTTGTCCCATTGGGGACTTGGCGGCGACTGTCCCTGTGCTGGTTTGCA
  GTGTGTGGGTTCATTCACCTGGTGATCGAGGGCTGGTTCGTTCTCTACTACGAAGACCTG
  CTTGGAGACCAAGCCTTCTTATCTCAACTCTGGAAAGAGTATGCCAAGGGAGACAGCCGA
  TACATCCTGGGTGACAACTTCACAGTGTGCATGGAAACCATCACAGCTTGCCTGTGGGGA
  CCACTCAGCCTGTGGGTGGTGATCGCCTTTCTCCGCCAGCATCCCCTCCGCTTCATTCTA
  CAGCTTGTGGTCTCTGTGGGCCAGATCTATGGGGATGTGCTCTACTTTCCTGACAGAGCA
  CCGCGACGGATTCCAGCACGGAGAGCTGGGCCACCCTCTCTACTCTGGTTTACTTTGTCT
  TCATGAATGCCCTGTGCTGTGCTGCCTGGAGTCTTGTGCTGATGCTGTGAGCACTCACTC
  ATGCCCAGAGCACGCTGATGCATGCACAAAGCAGACAGAGACTGAGATGTGACAGCTGAA
  CCTGCAGGAGGACTTCTGCCTGCCAAAAATCTAGTCTG
• Restriction Sites: Please inquire
• ACCN: NM_006579
• ORF Size: 693 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006579.1, NP_006570.1
• RefSeq Size: 1073
• RefSeq ORF: 693
• Locus ID: 10682
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Metabolic pathways, Steroid biosynthesis
• Gene Summary: The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]