Cullin 3 (CUL3) (NM_003590) Human Untagged Clone

CAT#: SC322625

CUL3 (untagged)-Human cullin 3 (CUL3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CUL3
• Synonyms: CUL-3; PHA2E
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322625 CCGGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATA
  AAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCC
  CAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGC
  GGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCC
  CAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGA
  CCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGC
  AGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATAT
  GTAAACAGCATTTGGGACCTTCTGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAAC
  AGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCATAAACAT
  GGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTG
  CGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGG
  AATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGGACCGTGTG
  TATGTACAACAAAATAATGTGGAGAACGTCTACAATTTGGGATTAATTATTTTTCGAGAT
  CAAGTTGTACGTTATGGGTGTATTAGGGATCATCTACGGCAAACTCTATTGGATATGATT
  GCAAGAGAGCGGAAAGGAGAAGTCGTAGACAGAGGCGCAATAAGAAATGCTTGCCAGATG
  TTAATGATTTTAGGTCTCGAAGGAAGATCAGTCTATGAAGAAGATTTTGAGGCTCCTTTT
  TTGGAAATGTCTGCAGAATTTTTTCAGATGGAAAGCCAGAAATTTTTAGCAGAAAATAGT
  GCTTCAGTATATATAAAGAAAGTAGAAGCTAGAATTAATGAAGAAATAGAACGAGTGATG
  CACTGCCTTGACAAATCAACGGAAGAACCAATTGTAAAGGTGGTTGAAAGGGAACTCATT
  TCCAAGCACATGAAGACTATAGTAGAAATGGAGAATTCTGGGCTAGTACATATGTTGAAA
  AATGGAAAGACAGAAGACCTTGGTTGCATGTACAAGTTATTTAGTCGTGTGCCAAATGGT
  TTGAAAACAATGTGTGAGTGTATGAGTTCCTATTTGAGGGAGCAAGGTAAAGCTCTTGTT
  TCTGAAGAAGGAGAAGGAAAGAATCCTGTTGACTATATCCAGGGCTTATTGGATCTGAAG
  AGTAGGTTCGATCGCTTCCTCCTGGAATCATTCAACAATGACCGTCTCTTTAAACAAACT
  ATTGCGGGTGACTTTGAGTATTTTCTCAACCTCAACTCCAGGTCTCCTGAATACCTCTCA
  TTATTTATTGATGATAAGCTGAAAAAGGGAGTCAAAGGGCTAACAGAACAAGAAGTAGAA
  ACAATATTGGATAAAGCAATGGTCCTTTTTAGGTTTATGCAAGAAAAAGATGTATTTGAA
  CGTTATTATAAACAACACTTGGCAAGGAGACTTCTCACAAATAAAAGTGTTTCTGATGAC
  TCTGAAAAAAACATGATATCTAAGTTAAAGACTGAATGTGGATGTCAGTTCACGTCAAAA
  CTGGAAGGAATGTTTAGGGATATGAGCATCTCAAACACAACGATGGATGAATTCAGGCAA
  CATCTACAGGCAACTGGTGTATCTTTAGGTGGTGTTGATCTTACAGTCCGGGTGCTCACG
  ACAGGATATTGGCCCACTCAGTCAGCCACACCAAAGTGCAACATCCCACCAGCACCAAGA
  CATGCTTTTGAGATATTCAGAAGGTTCTACTTAGCCAAACACAGTGGTCGACAGCTCACA
  CTCCAGCATCATATGGGTTCTGCAGATCTCAATGCCACATTTTATGGACCAGTTAAAAAG
  GAAGATGGATCTGAAGTTGGTGTTGGAGGTGCACAAGTAACTGGCTCTAATACACGGAAG
  CACATATTGCAAGTTTCCACTTTCCAGATGACCATATTAATGCTCTTTAATAATAGAGAA
  AAATACACATTTGAGGAAATTCAGCAAGAGACAGATATCCCTGAAAGAGAGCTTGTTAGA
  GCCCTACAGTCCCTCGCCTGTGGTAAACCAACACAGCGGGTTCTTACAAAAGAACCCAAA
  TCAAAGGAAATAGAAAATGGTCATATATTTACAGTTAATGATCAGTTCACATCCAAACTA
  CACAGAGTCAAGATTCAAACAGTTGCTGCCAAACAAGGTGAATCCGACCCAGAGAGGAAA
  GAAACAAGGCAGAAAGTAGACGACGACAGAAAACATGAGATAGAAGCTGCTATAGTGCGG
  ATAATGAAATCTAGAAAGAAGATGCAGCACAATGTTCTAGTAGCGGAGGTAACTCAGCAG
  TTGAAGGCGCGATTCTTACCAAGTCCAGTTGTTATTAAGAAACGTATTGAAGGACTTATT
  GAGAGAGAATATTTGGCACGAACACCTGAGGATCGCAAAGTATACACATATGTAGCATAA
  AATGCGTTCAGAAATTTGATTTATTCTTGGACTGTACTCTTCGCATGGACTGGGAAGTTC
  TTTTAAATCATTAAATATTAAGACGACCATCTCTTCTATTAAATTACAGTACATGTTCTA
  GACCATTGAGATCAAGCCTTTACTCCCTTTGAGAGTTTCCAACATCAGTTGATTGAGCTT
  CAGGCTTTACAACGTTTATCCCTGTAGAGATCATCTTTACAGTTCCTCGGGAAAATGTGA
  ATGTGCTGCGTTTTGTTTTCTTTACTGTATGAAAACAGGAAAATAAAAGAGAAATTTAGA
  AAATACAGCTCATTACAATAAAATTGTTGGATTTCAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC322625 unedited
  GTACGTACCATATGTATACGACTCCTATAGGGCGGAAGAAAAAACGCGGGCGCCGGTACC
  GGTCCGGAAAAAAAGGGATATCGTCGACCCACGCGTCCGCCCACGCGTCCGGCGCAGTGA
  GATGTTGGTCCGTCGCTTTCCGCCGACGCCAGCGGGGAGGAGCGCGATAAAGGGAGCCGA
  GCCGGACGTGAGGGGGACCCGGCCGAGCCGCCGCGCCGGCACAGCCCCCCACCCGCATCG
  GAGTCGCCAGAGTCCGAACCGCCGCCGACGACGCCCCCGGCGTCGCCGCGGCTGCCCAGG
  GGCCGCCCGCTCCCCGCCCTGCCCGGGGGTCGCGCCGCGGACGCCCCCAGCAACACCCCT
  TTCCTGCCTGCCCGGCTTAAATGTGACACCGGCGTCTTGGATCGCTACCAGAAGCCCTCG
  CCTGGGAGGGGACGATCACCATGTCGTATCTCAGCAAGGCACGGGCCGACGGAAGGACCC
  TAAGATGCGGATGCCGCCCCTGTCCGAGGACCCTGGGATGAAAAGACATGTGTAACCCTT
  TTTCGGGGACCTTTCAGAAAAAGGCTCTTCCCAGAGAATCCAAGGAAAAAATAACCAGCG
  GGTCTTAGGTCTGAGGGACCTGTATTAAAATGCCATACGGGTGGGTTTGGGCTAACCCCT
  GGTGTAAAAGCTTTCTCCCGGGTCTTAAAAAAAATTCTTTTCCCGACCCTCTCTTTAACT
  AAGGAGCCAAAAAGAGGGTACCTCAAATCTCGTTGAATATCCACTTGTTTTAAACACCTT
  AAATCAACCCTTGGCATTTTATCCTTCTAACACTTTTGGGGGTGTGGATTTTACAAAACA
  TCCGAATGGATCCCTGGCACCCGTGGTCTTGTCAACACAGCACAATATGGTGGGGAAAAC
  AGGTCTCA
• Restriction Sites: Please inquire
• ACCN: NM_003590
• ORF Size: 2307 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_003590.2, NP_003581.1
• RefSeq Size: 6787
• RefSeq ORF: 2307
• Locus ID: 8452
• Domains: CULLIN
• Protein Families: Druggable Genome
• Protein Pathways: Ubiquitin mediated proteolysis
• Gene Summary: This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
  Transcript Variant: This variant (1) encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.