IRAKM (IRAK3) (NM_007199) Human Untagged Clone

CAT#: SC323662

IRAK3 (untagged)-Kinase deficient mutant (K192M) of Human interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1


  "NM_007199" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IRAK3
Synonyms ASRT5; IRAKM
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC323662 sequence for NM_007199 edited (data generated by NextGen Sequencing)
ATGGCGGGGAACTGTGGGGCCCGCGGCGCGCTGTCGGCGCACACGCTGCTGTTCGACCTG
CCGCCCGCGCTGCTCGGAGAGCTCTGCGCTGTTCTGGACAGCTGCGACGGCGCGCTGGGC
TGGCGCGGCCTGGCAGAGAGACTTTCAAGCAGCTGGCTGGATGTTCGTCATATTGAAAAG
TATGTAGACCAAGGTAAAAGTGGAACAAGAGAATTACTTTGGTCCTGGGCACAGAAAAAC
AAGACCATCGGTGACCTTTTACAGGTCCTCCAGGAGATGGGACATCGTCGAGCTATTCAT
TTAATTACAAACTATGGAGCAGTGTTGAGTCCTTCAGAGAAGAGTTATCAGGAAGGTGGA
TTTCCAAATATATTATTCAAGGAAACAGCCAATGTCACCGTGGATAATGTTCTTATTCCT
GAACATAATGAAAAAGGAGTACTGCTTAAATCTTCCATCAGCTTTCAAAATATCATAGAA
GGAACTAGAAATTTCCACAAAGACTTCCTAATTGGAGAAGGAGAGATTTTTGAGGTATAC
AGAGTGGAGATTCAAAACCTAACATATGCTGTCATGTTATTTAAACAGGAGAAAAAAATG
CAGTGTAAGAAGCATTGGAAGAGGTTTTTATCTGAGCTTGAAGTTTTACTACTGTTTCAT
CACCCAAACATACTAGAGTTGGCTGCATATTTTACAGAGACTGAGAAGTTCTGTCTGATT
TATCCATACATGAGAAATGGAACACTTTTTGACAGATTGCAGTGTGTAGGTGACACGGCC
CCACTCCCTTGGCACATTCGAATCGGTATATTAATAGGAATATCCAAAGCCATTCACTAC
CTGCACAACGTTCAACCATGCTCGGTCATCTGTGGCAGTATATCAAGTGCAAACATCCTT
TTGGATGATCAGTTTCAACCCAAACTAACTGATTTTGCCATGGCACACTTCCGGTCCCAC
CTAGAACATCAGAGTTGTACCATAAATATGACCAGCAGCAGCAGTAAACATCTGTGGTAC
ATGCCAGAAGAGTACATCAGACAGGGGAAACTTTCCATTAAAACAGATGTCTACAGCTTT
GGAATTGTAATAATGGAAGTTCTAACAGGATGTAGAGTAGTGTTAGATGATCCAAAACAT
ATCCAGCTGCGGGATCTCCTTAGAGAATTGATGGAGAAGAGAGGCCTGGATTCATGTCTC
TCATTTCTAGATAAGAAAGTGCCTCCCTGCCCTCGGAATTTCTCTGCCAAGCTCTTCTGT
TTGGCAGGCCGGTGTGCTGCAACGCGGGCAAAGTTAAGACCATCAATGGATGAAGTTTTA
AATACTCTTGAAAGTACTCAAGCCAGCTTGTATTTTGCTGAAGATCCTCCCACATCACTA
AAGTCCTTCAGGTGTCCTTCTCCTCTATTCCTGGAGAATGTACCAAGTATTCCAGTGGAA
GATGATGAAAGCCAGAATAACAATTTACTACCTTCTGATGAAGGCCTGAGGATAGACAGA
ATGACTCAGAAAACTCCTTTTGAATGCAGCCAGTCTGAGGTTATGTTTCTGAGCTTGGAC
AAAAAGCCAGAGAGCAAGAGAAATGAGGAAGCTTGCAACATGCCCAGTTCTTCTTGTGAA
GAAAGTTGGTTCCCAAAGTATATAGTTCCATCCCAGGACTTAAGGCCCTATAAGGTAAAT
ATAGATCCTTCTTCAGAAGCTCCAGGGCATTCTTGCAGGAGCAGGCCAGTGGAGAGCAGC
TGTTCCTCCAAATTTTCCTGGGATGAATATGAACAGTACAAAAAAGAATAA

Clone variation with respect to NM_007199.2
439 a=>g;575 a=>t;576 a=>g
>OriGene 5' read for mutant NM_007199 unedited
ACCGCCCGTTGAGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGA
ACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACCAGGGCCTGTCGCAGGC
GTGCAGGGACCTGGACTCCGCCTCGTCCCCGGGGCTCGGGCAGCCGAGCCATGGCGGGGAACTGTGGGGC
CCGCGGCGCGCTGTCGGCGCACACGCTGCTGTTCGACCTGCCGCCCGCGCTGCTCGGAGAGCTCTGCGCT
GTTCTGGACAGCTGCGACGGGCGCGCTGGGCTGGGCGCGGCCTGGCAGAGAGAACTTTTCAAGCAGGCTG
TGGCGGGGATGGTTCGTCCATATTGAAAAAGTATGGTAAGACACCAAGGGTTAAAGTGTGGACAAGAGAA
AATAACCTTTGGTCCCTGGGGCCCAGAAAAAACAAGAACCATCGTTGAACCCTTTAACAGGGTCCCTCCC
AGAAGAATGGACACATCGCCAAACTATTTTCTTTTATTTTCCAAACCAATGGGACCCTGGGTTGAATTCC
TTTCAAAAAAAAATTTTTACGGGAGGGGGGGATTTCCCAAATATTTTTTTCAGGGGAACCCCCCAAGGGT
CCCCGGGGGAAAAGTGTTTTATTTTCCGGCCCATAGGGAAGGGGGTCTGGGGTTTAACTTTTCCCCTCCC
CTTTTTAAAAATTCTAAAAAGGGACCTAAAATTTTTCCACAAAAAAATCTCCAATTGGGGAAAAGGAAGA
AATTTTTTTGGGGGTACCAAAGAGGGGAATATACAAACCCACCCCACATCTGGTCCCGGTGCGGTTTAAC
ACACGGGAAGAAAATAGCATGTCGTTGTGAAGACACCTGTGGGAAGAGATGTGTTTCTCGGCATCGCATG
TATTTTACGGATGTGCTGTACTCCCGCAACATCACTAGTGGTGTGCGTATATTATTCGACAGCAACGCA
>SC323662 kinase domain raw sequence. By performing BLASTX analysis with this sequence against NCBI refernce protein database, you can confirm the presence of the kinase-deficient mutation
CCATGMGCAATGGGCGKAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCA
GAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACCAGGGCCTGTCGCAGGCGTGCAGG
GACCTGGACTCCGCCTCGTCCCCGGGGCTCGGGCAGCCGAGCCATGGCGGGGAACTGTGGGGCCCGCGGC
GCGCTGTCGGCGCACACGCTGCTGTTCGACCTGCCGCCCGCGCTG
Restriction Sites Please inquire     
ACCN NM_007199
ORF Size 1791 bp
Insert Size 2500
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
Reference Data
RefSeq NM_007199.1, NP_009130.1
RefSeq Size 2288
RefSeq ORF 1791
Locus ID 11213
Domains DEATH, pkinase, TyrKc, S_TKc
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Apoptosis, Neurotrophin signaling pathway
Gene Summary This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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