SLC22A17 (NM_020372) Human Untagged Clone

CAT#: SC324121

SLC22A17 (untagged)-Human solute carrier family 22, member 17 (SLC22A17), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SLC22A17
• Synonyms: 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_020372.2 GCCAGCAGCTGCAGCTCGGCCTCTGCTGCCTGCCGGTGCTCTTCGTGGCTCTGGGCATGG
  CCTCGGACCCCATCTTCACGCTGGCGCCCCCGCTGCATTGCCACTACGGGGCCTTCCCCC
  CTAATGCCTCTGGCTGGGAGCAGCCTCCCAATGCCAGCGGCGTCAGCGTCGCCAGCGCTG
  CCCTAGCAGCCAGCGCCGCCAGCCGTGTCGCCACCAGTACCGACCCCTCGTGCAGCGGCT
  TCGCCCCGCCGGACTTCAACCATTGCCTCAAGGATTGGGACTATAATGGCCTTCCTGTGC
  TCACCACCAACGCCATCGGCCAGTGGGATCTGGTGTGTGACCTGGGCTGGCAGGTGATCC
  TGGAGCAGATCCTCTTCATCTTGGGCTTTGCCTCCGGCTACCTGTTCCTGGGTTACCCCG
  CAGACAGATTTGGCCGTCGCGGGATTGTGCTGCTGACCTTGGGGCTGGTGGGCCCCTGTG
  GAGTAGGAGGGGCTGCTGCAGGCTCCTCCACAGGCGTCATGGCCCTCCGATTCCTCTTGG
  GCTTTCTGCTTGCCGGTGTTGACCTGGGTGTCTACCTGATGCGCCTGGAGCTGTGCGACC
  CAACCCAGAGGCTTCGGGTGGCCCTGGCAGGGGAGTTGGTGGGGGTGGGAGGGCACTTCC
  TGTTCCTGGGCCTGGCCCTTGTCTCTAAGGATTGGCGATTCCTACAGCGAATGATCACCG
  CTCCCTGCATCCTCTTCCTGTTTTATGGCTGGCCTGGTTTGTTCCTGGAGTCCGCACGGT
  GGCTGATAGTGAAGCGGCAGATTGAGGAGGCTCAGTCTGTGCTGAGGATCCTGGCTGAGC
  GAAACCGGCCCCATGGGCAGATGCTGGGGGAGGAGGCCCAGGAGGCCCTGCAGGACCTGG
  AGAATACCTGCCCTCTCCCTGCAACATCCTCCTTTTCCTTTGCTTCCCTCCTCAACTACC
  GCAACATCTGGAAAAATCTGCTTATCCTGGGCTTCACCAACTTCATTGCCCATGCCATTC
  GCCACTGCTACCAGCCTGTGGGAGGAGGAGGGAGCCCATCGGACTTCTACCTGTGCTCTC
  TGCTGGCCAGCGGCACCGCAGCCCTGGCCTGTGTCTTCCTGGGGGTCACCGTGGACCGAT
  TTGGCCGCCGGGGCATCCTTCTTCTCTCCATGACCCTTACCGGCATTGCTTCCCTGGTCC
  TGCTGGGCCTGTGGGATTGTGAGCATCCTATCTTCCCCACAGTGTGGGCTCAACAAGGGA
  ACCCCAACAGAGATCTGAACGAGGCTGCCATCACCACTTTCTCTGTCCTTGGGCTCTTCT
  CCTCCCAAGCTGCCGCCATCCTCAGCACCCTCCTTGCTGCTGAGGTCATCCCCACCACTG
  TCCGGGGCCGTGGCCTGGGCCTGATCATGGCTCTAGGGGCGCTTGGAGGACTGAGCGGCC
  CGGCCCAGCGCCTCCACATGGGCCATGGAGCCTTCCTGCAGCACGTGGTGCTGGCGGCCT
  GCGCCCTCCTCTGCATTCTCAGCATTATGCTGCTGCCGGAGACCAAGCGCAAGCTCCTGC
  CCGAGGTGCTCCGGGACGGGGAGCTGTGTCGCCGGCCTTCCCTGCTGCGGCAGCCACCCC
  CTACCCGCTGTGACCACGTCCCGCTGCTTGCCACCCCCAACCCTGCCCTCTGAGCGGCCT
  CTGAGTACCCTGGCGGGAGGCTGGCCCACACAGAAAGGTGGCAAGAAGATCGGGAAGACT
  GAGTAGGGAAGGCAGGGCTGCCCAGAAGTCTCAGAGGCACCTCACGCCAGCCATCGCGGA
  GAGCTCAGAGGGCCGTCCCCACCCTGCCTCCTCCCTGCTGCTTTGCATTCACTTCCTTGG
  CCAGAGTCAGGGGACAGGGAGAGAGCTCCACACTGTAACCACTGGGTCTGGGCTCCATCC
  TGCGCCCAAAGACATCCACCCAGACCTCATTATTTCTTGCTCTATCATTCTGTTTCAATA
  AAGACATTTGGAATAAACGAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_020372.2 unedited
  GGCACTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATATCGTCGACCCACGCGTCCGGCCAGCAGCTGCAGCTCGGCCTCTGCT
  GCCTGCCGGTGCTCTTCGTGGCTCTGGGCATGGCCTCGGACCCCATCTTCACGCTGGCGC
  CCCCGCTGCATTGCCACTACGGGGCCTTCCCCCCTAATGCCTCTGGCTGGGAGCAGCCTC
  CCAATGCCAGCGGCGTCAGCGTCGCCAGCGCTGCCCTAGCAGCCAGCGCCGCCAGCCGTG
  TCGCCACCAGTACCGACCCCTCGTGCAGCGGCTTCGCCCCGCCGGACTTCAACCATTGCC
  TCAAGGATTGGGACTATAATGGCCTTCCTGTGCTCACCACCAACGCCATCGGCCAGTGGG
  ATCTGGTGTGTGACCTGGGCTGGCAGGTGATCCTGGAGCAGATCCTCTTCATCTTGGGCT
  TTGCCTCCGGCTACCTGTTCCTGGGTTACCCCGCAGACAGATTTGGCCGTCGCGGGATTG
  TGCTGCTGACCTTGGGGCTGGTGGGCCCCTGTGGAGTAGGAGGGGCTGCTGCAGGCTCCT
  CCACAGGCGTCATGGCCCTCCCGATTCCCTCTTGGGCTTTCTGCTTGCCGGTGTTGACCC
  TGGGTGTCTACCTGATGCGCCTGGATCTGTGCGACCCCAGCCCATAGCTTTAGGGGGGGC
  CCTGTAACGAGAAATGGTGGAGGAGAAAAGCCATCTCCCC
• Restriction Sites: ECoRI-NOT
• ACCN: NM_020372
• ORF Size: 1617 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_020372.2, NP_065105.2
• RefSeq Size: 2090
• RefSeq ORF: 1617
• Locus ID: 51310
• Domains: sugar_tr
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) encodes the longest isoform (a).