SV2B (NM_001167580) Human Untagged Clone

CAT#: SC328878

SV2B (untagged)-Human synaptic vesicle glycoprotein 2B (SV2B) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SV2B
• Synonyms: HsT19680
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001167580, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGATAGTCTACTTGGGAATGATGGCGGGCGCCTTCATCCTGGGAGGCCTGGCTGATAAGCTGGGAAGGA
  AGCGAGTCCTCAGCATGTCTCTGGCCGTCAATGCCTCCTTCGCCTCCCTCTCTTCCTTCGTGCAGGGATA
  TGGAGCCTTCCTCTTCTGCCGACTCATCTCAGGCATCGGTATTGGGGGTGCTCTACCGATTGTTTTTGCC
  TATTTTTCTGAATTCTTGTCTCGGGAGAAGCGAGGAGAACACCTCAGTTGGCTGGGCATCTTCTGGATGA
  CTGGGGGCCTGTACGCATCTGCCATGGCCTGGAGCATCATCCCACACTATGGCTGGGGCTTCAGCATGGG
  GACCAATTACCACTTCCATAGCTGGAGAGTGTTTGTCATCGTCTGTGCTCTGCCCTGCACCGTGTCCATG
  GTGGCCCTGAAGTTCATGCCAGAGAGCCCAAGGTTTCTGCTAGAGATGGGCAAACATGATGAAGCCTGGA
  TGATTCTCAAGCAAGTCCATGACACCAACATGAGAGCTAAGGGGACCCCAGAGAAAGTGTTCACGGTTTC
  CAACATCAAAACTCCCAAGCAAATGGATGAATTCATTGAGATCCAAAGTTCAACAGGAACCTGGTACCAG
  CGCTGGCTGGTCAGATTCAAGACCATTTTCAAGCAGGTCTGGGATAATGCCCTGTACTGTGTGATGGGGC
  CCTACAGAATGAATACACTGATTCTGGCCGTGGTTTGGTTTGCCATGGCATTCAGTTACTATGGACTGAC
  AGTTTGGTTTCCTGATATGATCCGCTATTTTCAAGATGAAGAATACAAGTCTAAAATGAAGGTGTTTTTT
  GGTGAGCATGTGTACGGCGCCACAATCAACTTCACGATGGAAAATCAGATCCACCAACATGGGAAACTTG
  TGAATGATAAGTTCACAAGAATGTACTTTAAACATGTACTCTTTGAGGACACATTCTTTGACGAGTGCTA
  TTTTGAAGACGTAACATCAACAGATACCTACTTCAAAAATTGTACCATTGAATCAACCATCTTTTACAAC
  ACAGACCTCTACGAGCACAAGTTCATCAACTGTCGGTTTATCAACTCCACCTTCCTGGAGCAGAAGGAGG
  GCTGCCACATGGACTTGGAGCAAGATAATGACTTCCTGATTTACCTCGTCAGCTTCCTGGGCAGCCTGTC
  TGTCTTACCCGGGAACATCATTTCTGCCCTGCTCATGGATAGAATTGGAAGGCTCAAGATGATTGGTGGC
  TCCATGCTAATCTCTGCAGTCTGCTGCTTCTTCCTGTTTTTTGGCAACAGTGAGTCTGCAATGATCGGCT
  GGCAGTGCCTGTTCTGTGGGACAAGCATTGCAGCCTGGAATGCTCTGGATGTGATCACAGTGGAGCTGTA
  TCCCACCAACCAGAGAGCAACAGCCTTCGGCATTCTCAATGGATTATGCAAATTTGGCGCCATCCTGGGA
  AACACCATCTTTGCTTCTTTTGTTGGGATAACCAAAGTGGTCCCCATCCTTCTGGCTGCTGCTTCTCTGG
  TTGGGGGTGGCCTGATTGCCCTTCGACTGCCAGAGACTCGAGAACAGGTCCTGATGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001167580
• ORF Size: 1599 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001167580.1, NP_001161052.1
• RefSeq Size: 10788
• RefSeq ORF: 1599
• Locus ID: 9899
• Protein Families: Secreted Protein, Transmembrane
• Protein Pathways: ECM-receptor interaction
• Gene Summary: This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]
  Transcript Variant: This variant (2) lacks two internal exons in the 5' region, as compared to variant 1. This results in a downstream in-frame AUG start codon and a shorter isoform (2), as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.