Human RAGE (AGER) activation kit by CRISPRa

CAT#: GA100125

AGER CRISPRa kit - CRISPR gene activation of human advanced glycosylation end-product specific receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AGER
• Locus ID: 177
• Kit Components:

  GA100125G1, RAGE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100125G2, RAGE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100125G3, RAGE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136, NM_001206929, NM_001206932, NM_001206934, NM_001206936, NM_001206940, NM_001206954, NM_001206966, NM_172197, NR_038190
• Synonyms: RAGE
• Summary: 'The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]'