Human CHM activation kit by CRISPRa

CAT#: GA100801

CHM CRISPRa kit - CRISPR gene activation of human CHM Rab escort protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHM
• Locus ID: 1121
• Kit Components:

  GA100801G1, CHM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100801G2, CHM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100801G3, CHM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000390, NM_001037312, NM_001145414, NM_001320959, NM_001362519, NM_001362517, NM_001362518
• Synonyms: DXS540; GGTA; HSD-32; REP-1; TCD
• Summary: 'This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]'