Human CST6 activation kit by CRISPRa

CAT#: GA101042

CST6 CRISPRa kit - CRISPR gene activation of human cystatin E/M

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CST6
• Locus ID: 1474
• Kit Components:

  GA101042G1, CST6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101042G2, CST6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101042G3, CST6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001323
• Synonyms: cystatin 6; cystatin E/M; cystatin M; cystatin M/E; cysteine proteinase inhibitor
• Summary: 'The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]'