Human CYP24A1 activation kit by CRISPRa

CAT#: GA101119

CYP24A1 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 24 subfamily A member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP24A1
• Locus ID: 1591
• Kit Components:

  GA101119G1, CYP24A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101119G2, CYP24A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101119G3, CYP24A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000782, NM_001128915, N29030
• Synonyms: CP24; CYP24; HCAI; P450-CC24
• Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'