Human GABA A Receptor alpha 1 (GABRA1) activation kit by CRISPRa

CAT#: GA101697

GABRA1 CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type A receptor alpha1 subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GABRA1
• Locus ID: 2554
• Kit Components:

  GA101697G1, GABA A Receptor alpha 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101697G2, GABA A Receptor alpha 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101697G3, GABA A Receptor alpha 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000806, NM_001127643, NM_001127644, NM_001127645, NM_001127646, NM_001127647, NM_001127648
• Synonyms: ECA4; EIEE19; EJM; EJM5
• Summary: 'This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]'