Human GDNF Receptor alpha 1 (GFRA1) activation kit by CRISPRa

CAT#: GA101786

GFRA1 CRISPRa kit - CRISPR gene activation of human GDNF family receptor alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GFRA1
• Locus ID: 2674
• Kit Components:

  GA101786G1, GDNF Receptor alpha 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101786G2, GDNF Receptor alpha 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101786G3, GDNF Receptor alpha 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145453, NM_005264, NM_145793, NM_001348096, NM_001348097, NM_001348098, NM_001348099
• Synonyms: GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1
• Summary: 'This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]'