Human Neuropeptide Y (NPY) activation kit by CRISPRa

CAT#: GA103239

NPY CRISPRa kit - CRISPR gene activation of human neuropeptide Y

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NPY
• Locus ID: 4852
• Kit Components:

  GA103239G1, Neuropeptide Y gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103239G2, Neuropeptide Y gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103239G3, Neuropeptide Y gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000905
• Synonyms: PYY4
• Summary: 'This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]'