Human Properdin (CFP) activation kit by CRISPRa

CAT#: GA103491

CFP CRISPRa kit - CRISPR gene activation of human complement factor properdin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CFP
• Locus ID: 5199
• Kit Components:

  GA103491G1, Properdin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103491G2, Properdin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103491G3, Properdin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145252, NM_002621
• Synonyms: BFD; PFC; PFD; PROPERDIN
• Summary: 'This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]'