Human Papillary renal cell carcinoma (PRCC) activation kit by CRISPRa

CAT#: GA103743

PRCC CRISPRa kit - CRISPR gene activation of human proline rich mitotic checkpoint control factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRCC
• Locus ID: 5546
• Kit Components:

  GA103743G1, Papillary renal cell carcinoma gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103743G2, Papillary renal cell carcinoma gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103743G3, Papillary renal cell carcinoma gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005973, NM_199416
• Synonyms: RCCP1; TPRC
• Summary: 'This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]'