Human Tuberin (TSC2) activation kit by CRISPRa

CAT#: GA104987

TSC2 CRISPRa kit - CRISPR gene activation of human TSC complex subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TSC2
• Locus ID: 7249
• Kit Components:

  GA104987G1, Tuberin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104987G2, Tuberin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104987G3, Tuberin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000548, NM_001077183, NM_001114382, NM_001318827, NM_001318829, NM_001318831, NM_001318832, NM_021055, NM_021056, NM_001363528, NM_001370405, NM_001370404
• Synonyms: LAM; PPP1R160; TSC4
• Summary: 'Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]'