Human LGR5 activation kit by CRISPRa

CAT#: GA105663

LGR5 CRISPRa kit - CRISPR gene activation of human leucine rich repeat containing G protein-coupled receptor 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LGR5
• Locus ID: 8549
• Kit Components:

  GA105663G1, LGR5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105663G2, LGR5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105663G3, LGR5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001277226, NM_001277227, NM_003667, NR_110596
• Synonyms: FEX; GPR49; GPR67; GRP49; HG38
• Summary: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]