Human PEA15 activation kit by CRISPRa

CAT#: GA105759

PEA15 CRISPRa kit - CRISPR gene activation of human proliferation and apoptosis adaptor protein 15

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PEA15
• Locus ID: 8682
• Kit Components:

  GA105759G1, PEA15 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105759G2, PEA15 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105759G3, PEA15 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001297576, NM_001297577, NM_001297578, NM_003768, NM_013287, NR_123724
• Synonyms: HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED
• Summary: This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]