Human APOL3 activation kit by CRISPRa

CAT#: GA112997

APOL3 CRISPRa kit - CRISPR gene activation of human apolipoprotein L3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APOL3
• Locus ID: 80833
• Kit Components:

  GA112997G1, APOL3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112997G2, APOL3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112997G3, APOL3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014349, NM_030644, NM_145639, NM_145640, NM_145641, NM_145642, NR_027833, NR_027834, NR_027835
• Synonyms: APOLIII; apolipoprotein L, 3; apolipoprotein L-III; apolipoprotein L3; CG12-1; OTTHUMP00000028913; TNF-inducible protein CG12-1
• Summary: This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]