APOL3 Human Gene Knockout Kit (CRISPR)

CAT#: KN408325

APOL3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: APOL3
• Locus ID: 80833
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_014349, NM_030644, NM_145639, NM_145640, NM_145641, NM_145642, NR_027833, NR_027834, NR_027835
• Synonyms: APOLIII; apolipoprotein L, 3; apolipoprotein L-III; apolipoprotein L3; CG12-1; OTTHUMP00000028913; TNF-inducible protein CG12-1
• Summary: This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]