Human c20orf72 (MGME1) activation kit by CRISPRa

CAT#: GA114229

MGME1 CRISPRa kit - CRISPR gene activation of human mitochondrial genome maintenance exonuclease 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MGME1
• Locus ID: 92667
• Kit Components:

  GA114229G1, MGME1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114229G2, MGME1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114229G3, MGME1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001310338, NM_001310339, NM_052865, NM_001363738
• Synonyms: bA504H3.4; C20orf72; DDK1; MTDPS11
• Summary: The protein encoded by this gene is a nuclear-encoded mitochondrial protein necessary for the maintenance of mitochondrial genome synthesis. The encoded protein is a RecB-type exonuclease and primarily cleaves single-stranded DNA. Defects in this gene have been associated with mitochondrial DNA depletion syndrome-11. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]