Human IL28 Receptor alpha (IFNLR1) activation kit by CRISPRa

CAT#: GA116094

IFNLR1 CRISPRa kit - CRISPR gene activation of human interferon lambda receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IFNLR1
• Locus ID: 163702
• Kit Components:

  GA116094G1, IFNLR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116094G2, IFNLR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116094G3, IFNLR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_170743, NM_173064, NM_173065
• Synonyms: CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2
• Summary: The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]