Human SLC26A5 activation kit by CRISPRa

CAT#: GA117826

SLC26A5 CRISPRa kit - CRISPR gene activation of human solute carrier family 26 member 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC26A5
• Locus ID: 375611
• Kit Components:

  GA117826G1, SLC26A5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117826G2, SLC26A5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117826G3, SLC26A5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001167962, NM_001321787, NM_198999, NM_206883, NM_206884, NM_206885, NR_120441, NR_120442, NR_120443, NR_135801, NR_135802
• Synonyms: DFNB61; PRES
• Summary: This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]