Mouse Gnrh1 activation kit by CRISPRa

CAT#: GA201677

Gnrh1 CRISPRa kit - CRISPR gene activation of mouse gonadotropin releasing hormone 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gnrh1
• Locus ID: 14714
• Kit Components:

  GA201677G1, Gnrh1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201677G2, Gnrh1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201677G3, Gnrh1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008145, NR_133010
• Synonyms: Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh
• Summary: This gene encodes hypophysiotropic peptides belonging to the family of gonadotropin-releasing hormones that stimulate the release of gonadotropins and suppress secretion of prolactin from the pituitary gland. The encoded protein is proteolytically processed to generate two biologically active mature peptides. A deletional mutation encompassing the distal half of this gene in mice resulting in the loss of the encoded protein leads to hypogonadism and infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]