Mouse Cgas activation kit by CRISPRa

CAT#: GA213232

Cgas CRISPRa kit - CRISPR gene activation of mouse cyclic GMP-AMP synthase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cgas
• Locus ID: 214763
• Kit Components:

  GA213232G1, Cgas gRNA vector 1 in pCas-Guide-CRISPRa

  GA213232G2, Cgas gRNA vector 2 in pCas-Guide-CRISPRa

  GA213232G3, Cgas gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_173386, NR_125721
• Synonyms: cGAS; E330016A19Rik
• Summary: The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]