RACGAP1 Human Gene Knockout Kit (CRISPR)

CAT#: KN407542

RACGAP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: RACGAP1
• Locus ID: 29127
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001126103, NM_001126104, NM_001319999, NM_001320000, NM_001320001, NM_001320002, NM_001320003, NM_001320004, NM_001320005, NM_001320006, NM_001320007, NM_013277
• Synonyms: CYK4; HsCYK-4; ID-GAP; MgcRacGAP
• Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]