PTPRN (NM_002846) Human Recombinant Protein

CAT#: TP710233

Purified recombinant protein of Human protein tyrosine phosphatase, receptor type, N (PTPRN), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9 insect cells

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: Sf9
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, RC220230, encoding human full-length PTPRN
• Tag: C-DDK
• Predicted MW: 103 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_002837
• Locus ID: 5798
• UniProt ID: Q16849, Q96IA0
• Cytogenetics: 2q35
• Refseq Size: 3649
• Refseq ORF: 2937
• Synonyms: IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N
• Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]'
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Type I diabetes mellitus