CD33 (NM_001772) Human Recombinant Protein
CAT#: TP720665
Purified recombinant protein of Human CD33 molecule (CD33), transcript variant 1
Product Images
![](https://cdn.origene.com/img/defaults-img.jpg)
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
Asp18-His259
|
Tag | C-hFc&His |
Predicted MW | 55.01 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, 5% Trehalose, 0.01%Tween 80, pH7.2 |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_001763 |
Locus ID | 945 |
UniProt ID | P20138, Q546G0 |
Cytogenetics | 19q13.41 |
Refseq Size | 1466 |
Refseq ORF | 1092 |
Synonyms | p67; SIGLEC-3; SIGLEC3 |
Summary | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).[UniProtKB/Swiss-Prot Function] |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Hematopoietic cell lineage |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400667 | CD33 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC421195 | CD33 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC425947 | CD33 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC432863 | CD33 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LY400667 | Transient overexpression lysate of CD33 molecule (CD33), transcript variant 1 |
USD 396.00 |
|
LY421195 | Transient overexpression lysate of CD33 molecule (CD33), transcript variant 2 |
USD 396.00 |
|
LY425947 | Transient overexpression lysate of CD33 molecule (CD33), transcript variant 2 |
USD 396.00 |
|
LY432863 | Transient overexpression lysate of CD33 molecule (CD33), transcript variant 3 |
USD 396.00 |
|
PH307023 | CD33 MS Standard C13 and N15-labeled recombinant protein (NP_001763) |
USD 2,055.00 |
|
PH317716 | CD33 MS Standard C13 and N15-labeled recombinant protein (NP_001076087) |
USD 2,055.00 |
|
TP307023 | Recombinant protein of human CD33 molecule (CD33), transcript variant 1 |
USD 823.00 |
|
TP317716 | Purified recombinant protein of Homo sapiens CD33 molecule (CD33), transcript variant 2 |
USD 823.00 |
{0} Product Review(s)
Be the first one to submit a review