PRAS40 (AKT1S1) Rabbit Polyclonal Antibody

CAT#: TA349158

Rabbit Polyclonal Anti-HOPX Antibody

Product Images

Western blot analysis of HOPX in human brain tissue lysate with HOPX antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of HOPX in human heart tissue with HOPX antibody at 5 ug/mL.

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  Immunofluorescence of HOPX in human heart tissue with HOPX antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: HOPX antibody was raised against a 16 amino acid peptide near the amino terminus of human HOPX.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: HOPX antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 12 kDa; Observed: 183 kDa
• Gene Name: AKT1 substrate 1
• Database Link:
  NP_115751
  Entrez Gene 84335 Human
  UniProt ID Q96B36
• Background: HOPX is a small homeodomain protein that lacks normally conserved residues required for DNA binding (1). It is thought to act downstream of NKX2-5 and modulates serum response factor (SRF)-dependent cardiac-specific gene expression and cardiac development (1). HOPX also acts a tumor suppressor gene in multiple tumors and cancer cell lines (2,3). HOPX has been reported to regulate the proliferation/differentiation homeostasis in different cell types, including keratinocytes (4).
• Synonyms: Lobe; PRAS40