P4HB Mouse Monoclonal Antibody [Clone ID: 3G5]

CAT#: TA355380

P4HB Antibody

Product Images

WB Suggested Anti-P4HB Antibody Titration: 2.5 ug/ml Positive Control: THP-1 Whole Cell

Specifications

Product Data

• Clone Name: 3G5
• Applications: WB
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 58kDa
• Gene Name: prolyl 4-hydroxylase subunit beta
• Database Link:
  NP_000909
  Entrez Gene 5034 Human
  UniProt ID Q96C96
• Background: P4HB is the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
• Synonyms: DSI; ERBA2L; GIT; P4Hbeta; p55; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB

Reference Data

• Protein Families: Druggable Genome