AIRE Rabbit Polyclonal Antibody

CAT#: TA355554

AIRE Antibody - N-terminal region

Product Images

WB Suggested Anti-AIRE Antibody Titration: 5 ug/ml Positive Control: HepG2 Whole Cell

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
• Specificity: Expected reactivity: Cow, Dog, Horse, Human, Pig, Rat
  Homology: Cow: 79%; Dog: 92%; Horse: 86%; Human: 100%; Pig: 93%; Rat: 79%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Protein A purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted Protein Size: 58kDa
• Gene Name: autoimmune regulator
• Database Link:
  NP_000374
  Entrez Gene 326 Human
  UniProt ID O43918
• Background: AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
• Synonyms: AIRE1; APECED; APS1; APSI; OTTHUMP00000109529; PGA1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Primary immunodeficiency, Ubiquitin mediated proteolysis