IRAK4 (NM_016123) Human Untagged Clone

CAT#: SC114468

IRAK4 (untagged)-Human interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IRAK4
• Synonyms: IPD1; IRAK-4; NY-REN-64; REN64
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_016123 edited
  ATGAACAAACCCATAACACCATCAACATATGTGCGCTGCCTCAATGTTGGACTAATTAGG
  AAGCTGTCAGATTTTATTGATCCTCAAGAAGGATGGAAGAAGTTAGCTGTAGCTATTAAA
  AAACCATCTGGTGATGATAGATACAATCAGTTTCACATAAGGAGATTTGAAGCATTACTT
  CAAACTGGAAAAAGTCCCACTTCTGAATTACTGTTTGACTGGGGCACCACAAATTGCACA
  GTTGGTGATCTTGTGGATCTTTTGATCCAAAATGAATTTTTTGCTCCTGCGAGTCTTTTG
  CTCCCAGATGCTGTTCCCAAAACTGCTAATACACTACCTTCTAAAGAAGCTATAACAGTT
  CAGCAAAAACAGATGCCTTTCTGTGACAAAGACAGGACATTGATGACACCTGTGCAGAAT
  CTTGAACAAAGCTATATGCCACCTGACTCCTCAAGTCCAGAAAATAAAAGTTTAGAAGTT
  AGTGATACACGTTTTCACAGTTTTTCATTTTATGAATTGAAGAATGTCACAAATAACTTT
  GATGAACGACCCATTTCTGTTGGTGGTAATAAAATGGGAGAGGGAGGATTTGGAGTTGTA
  TATAAAGGCTACGTAAATAACACAACTGTGGCAGTGAAGAAGCTTGCAGCAATGGTTGAC
  ATTACTACTGAAGAACTGAAACAGCAGTTTGATCAAGAAATAAAAGTAATGGCAAAGTGT
  CAACATGAAAACTTAGTAGAACTACTTGGTTTCTCAAGTGATGGAGATGACCTCTGCTTA
  GTATATGTTTACATGCCTAATGGTTCATTGCTAGACAGACTCTCTTGCTTGGATGGTACT
  CCACCACTTTCTTGGCACATGAGATGCAAGATTGCTCAGGGTGCAGCTAATGGCATCAAT
  TTTCTACATGAAAATCATCATATTCATAGAGATATTAAAAGTGCAAATATCTTACTGGAT
  GAAGCTTTTACTGCTAAAATATCTGACTTTGGCCTTGCACGGGCTTCTGAGAAGTTTGCC
  CAGACAGTCATGACTAGCAGAATTGTGGGAACAACAGCTTATATGGCACCAGAAGCTTTG
  CGTGGAGAAATAACACCCAAATCTGATATTTACAGCTTTGGTGTGGTTTTACTAGAAATA
  ATAACTGGACTTCCAGCTGTGGATGAACACCGTGAACCTCAGTTATTGCTAGATATTAAA
  GAAGAAATTGAAGATGAAGAAAAGACAATTGAAGATTATATTGATAAAAAGATGAATGAT
  GCTGATTCCACTTCAGTTGAAGCTATGTACTCTGGTGCTAGCCAATGTCGGCATGAAAAG
  AAAAATAAGAGACCAGACATTAAGAAGGTTCAACAGCTGCTGCAAGAGATGACAGCTTCT
  TAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_016123 unedited
  GTAACGTACAAATTTTGTAATACGAACTCACTATAGGGCGGCCGCGAATTCGCACGAGGG
  TTCTTCTGTCGCCGGCTTCAGCAGCCCGCGCCCGGGCAGGAATAGAAGATGAACAAACCC
  ATAACACCATCAACATATGTGCGCTGCCTCAATGTTGGACTAATTAGGAAGCTGTCAGAT
  TTTATTGATCCTCAAGAAGGATGGAAGAAGTTAGCTGTAGCTATTAAAAAACCATCTGGT
  GATGATAGATACAATCAGTTTCACATAAGGAGATTTGAAGCATTACTTCAAACTGGAAAA
  AGTCCCACTTCTGAATTACTGTTTGACTGGGGCACCACAAATTGCACAGTTGGTGATCTT
  GTGGATCTTTTGATCCAAAATGAATTTTTTGCTCCTGCGAGTCTTTTGCTCCCAGATGCT
  GTTCCCAAAACTGCTAATACACTACCTTCTAAAGAAGCTATAACAGTTCAGCAAAAACAG
  ATGCCTTTCTGTGACAAAGACAGGACATTGATGACACCTGTGCAGAATCTTGAACAAAGC
  TATATGCCACCTGACTCCTCAAGTCCAGAAAATAAAAGTTTAGAAGTTAGTGATACACGT
  TTTCACAGTTTTTCATTTTATGAATTGAAGAATGTCACAAATAACTTTGATGAACGACCC
  ATTTCTGTTGGTGGTAATAAAATGGGAGAGGGAGGATTTGGAGTTGTATATAAAGGCTAC
  GTAAATAACACAACTGTGGCAGTGAAGAAGCTTGCAGCAATGGTTGACATTACTACTGGA
  GAACTGAAACAGCAGTTTGATCAAGAAATAAAAAGTATGGCAAAGTGTCAACATGAAAAC
  TTAGTAGAACTACTTGGTTTCTCAAGTGATGGAGATGACCTCTGCTTAGTATATGTTTAC
  ATGCCTAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_016123 unedited
  GGGGGAACTTGGGGGGATGNNGNCNCCTGNGTACCTGATTGTATTTATTTATGACTGGAG
  AGTCTCACTACTGTACACCCAGGGCTGAAGTGCCCCCGCCCCCCCCCTTTTTTTTTTTTT
  TTTTTGGGGGNGNCNCNNNNTGNNNCCCAGCCTGAACNCCCANATGGTGGGACTACAGGT
  GTCCACCACCACGCTCGTCTAATTTTTGTATTTTTAGAAAATTTGTTGTTTTACCATGTT
  GGCCAGGCCGGTCTTTTTCTGTTGACCTCAGGTGATCTGCCTGCCTCGGCCCCCCAAAGT
  GCTGGGATTTACGGGTATGAGCCACCACATCCAGCCAATGTGACCCATTATCTCTTTTTT
  TTTTATATCAAAAGTCCCGCACAGAACAAATTGATTCTCATACTGAGGATCATGCAAAGC
  TGAAATCCAGGTGTCAGCCCAGGCTGTGGTTATCATCTGAAGCTTGGAGTACTCTTTTAA
  GCTGACTCAGATTTTCGGGAGAATTCACTTCCTTGGGGTTGCAACTGAGGCCCCAATTTT
  TTTTCCTGCTTGCTAGACACTGGGAGGAAGGGCTCATCTCCTAGAGGCCACCTTTAGGTT
  TTAGCCAATGGGGCCCTCTCACATACTTCTTTAGGCTTACCAGGGAAATTCTTCTTGCAA
  GGGTTGCATTGATTAATGGAGGCCCTTTAAAAGTCCGAAAGGGAGTGGTTTGGCACCTTA
  ACGGCTGGGCCAAATTCCCTGAACCGTGGGCTGCAACTAATTCTTATGGGGGCGGGTAAA
  TTTGGCGGCCCTCATAAGGGATATTTCTTAATGGGGGAAAAAGACAATCTGTGGCCCTTA
  TTTTCGAAGTTCCCGGTCAAACGAATTTTGTCAACTGATGCAATAAAACTTTAACACGAG
  GGATTCTCTTCCATTTAACGACGGAGTTG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_016123
• ORF Size: 1383 bp
• Insert Size: 3000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_016123.1, NP_057207.1
• RefSeq Size: 2817
• RefSeq ORF: 1383
• Locus ID: 51135
• Domains: DEATH, pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 13 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.