IRAK4 (NM_016123) Human Untagged Clone

CAT#: SC320873

IRAK4 (untagged)-Human interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IRAK4
• Synonyms: IPD1; IRAK-4; NY-REN-64; REN64
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_016123.1 GGGGGCTTCCTAGTTCGGCTGGTTCTTCTGTCGCCGGCTTCAGCAGCCCGCGCCCGGGCA
  GGAATAGAAGATGAACAAACCCATAACACCATCAACATATGTGCGCTGCCTCAATGTTGG
  ACTAATTAGGAAGCTGTCAGATTTTATTGATCCTCAAGAAGGATGGAAGAAGTTAGCTGT
  AGCTATTAAAAAACCATCTGGTGATGATAGATACAATCAGTTTCACATAAGGAGATTTGA
  AGCATTACTTCAAACTGGAAAAAGTCCCACTTCTGAATTACTGTTTGACTGGGGCACCAC
  AAATTGCACAGTTGGTGATCTTGTGGATCTTTTGATCCAAAATGAATTTTTTGCTCCTGC
  AAGTCTTTTGCTCCCAGATGCTGTTCCCAAAACTGCTAATACACTACCTTCTAAAGAAGC
  TATAACAGTTCAGCAAAAACAGATGCCTTTCTGTGACAAAGACAGGACATTGATGACACC
  TGTGCAGAATCTTGAACAAAGCTATATGCCACCTGACTCCTCAAGTCCAGAAAATAAAAG
  TTTAGAAGTTAGTGATACACGTTTTCACAGTTTTTCATTTTATGAATTGAAGAATGTCAC
  AAATAACTTTGATGAACGACCCATTTCTGTTGGTGGTAATAAAATGGGAGAGGGAGGATT
  TGGAGTTGTATATAAAGGCTACGTAAATAACACAACTGTGGCAGTGAAGAAGCTTGCAGC
  AATGGTTGACATTACTACTGAAGAACTGAAACAGCAGTTTGATCAAGAAATAAAAGTAAT
  GGCAAAGTGTCAACATGAAAACTTAGTAGAACTACTTGGTTTCTCAAGTGATGGAGATGA
  CCTCTGCTTAGTATATGTTTACATGCCTAATGGTTCATTGCTAGACAGACTCTCTTGCTT
  GGATGGTACTCCACCACTTTCTTGGCACATGAGATGCAAGATTGCTCAGGGTGCAGCTAA
  TGGCATCAATTTTCTACATGAAAATCATCATATTCATAGAGATATTAAAAGTGCAAATAT
  CTTACTGGATGAAGCTTTTACTGCTAAAATATCTGACTTTGGCCTTGCACGGGCTTCTGA
  GAAGTTTGCCCAGACAGTCATGACTAGCAGAATTGTGGGAACAACAGCTTATATGGCACC
  AGAAGCTTTGCGTGGAGAAATAACACCCAAATCTGATATTTACAGCTTTGGTGTGGTTTT
  ACTAGAAATAATAACTGGACTTCCAGCTGTGGATGAACACCGTGAACCTCAGTTATTGCT
  AGATATTAAAGAAGAAATTGAAGATGAAGAAAAGACAATTGAAGATTATATTGATAAAAA
  GATGAATGATGCTGATTCCACTTCAGTTGAAGCTATGTACTCTGTTGCTAGTCAATGTCT
  GCATGAAAAGAAAAATAAGAGACCAGACATTAAGAAGGTTCAACAGCTGCTGCAAGAGAT
  GACAGCTTCTTAAAACTTTATTGGAAAAGACTCTTGACTTTTTATATACACCTATCTCAA
  CCATTTTTTTAACTGATTTTTTTCCTAAATATTCTTCTTTACCTTTAACAAGGCATAGGC
  TGTTGCAGGACAGTGGTTATTAAAGCATGGGTTGAACTTCCAAAAAAAAAAAAAAAAAAA
  AAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_016123.1 unedited
  GCATTGTATACGACTCCTATAGGGCGGCAGGGTAATTCGGCCATCTACGGCCGGGGGCTT
  CCTAGTTCGGCTGGTTCTTCTGTCGCCGGCTTCAGCAGCCCGCGCCCGGGCAGGAATAGA
  AGATGAACAAACCCATAACACCATCAACATATGTGCGCTGCCTCAATGTTGGACTAATTA
  GGAAGCTGTCAGATTTTATTGATCCTCAAGAAGGATGGAAGAAGTTAGCTGTAGCTATTA
  AAAAACCATCTGGTGATGATAGATACAATCAGTTTCACATAAGGAGATTTGAAGCATTAC
  TTCAAACTGGAAAAAGTCCCACTTCTGTTTTTCTGTTTGACTGGGGCACCACAAATTGCA
  CAGTTGGTGATCTTGTGGATCTTTTGATCCAAAATGAATTTTTTGCTCCTGCAAGTCTTT
  TGCTCCCAGATGCTGTTCCCAAAACTGCTAATACACTACCTTCTAAAGAAGCTATAACAG
  TTCAGCAAAAACAGATGCCTTTCTGTGACAAAGACAGGACATTGATGACACCTGTGCAGA
  ATCTTGAACAAAGCTATATGCCACCTGACTCCTCAAGTCCAGAAAATAAAAGTTTAGAAG
  TTAGTGATACACGTTTTCACAGTTTTTCATTTTATGAATTTGAAGAATGTCACAAATAAC
  TTTGATGAACGACCCATTTCTGTTGGTGGTAATAAAATGGAGAGGGAGGATTTGGAGTTG
  TATATAAAGGCTACGTAAATAACACACTGTGGCAGTGAAGAAGCTTGCAGCAATGGTTGA
  CATTACTACTGAGACTGAAACAGCAGTTTGATCAGAAATAAAGTAATGCAAGTGTCGACA
  TGAAGACTTAGTAGACTACTGGTTTCTCAGTGATGGAAATGACCTCTGCCTAAATTATGT
  TTACTGCCCTTATTGGTTTCATTGGCTAGACAGAGACTTCTCTTGGCTT
• Restriction Sites: Please inquire
• ACCN: NM_016123
• ORF Size: 1383 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_016123.1, NP_057207.1
• RefSeq Size: 2817
• RefSeq ORF: 1383
• Locus ID: 51135
• Domains: DEATH, pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 13 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.