ZP4 (NM_021186) Human Untagged Clone

CAT#: SC304918

ZP4 (untagged)-Human zona pellucida glycoprotein 4 (ZP4)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ZP4
• Synonyms: ZBP; Zp-4; ZP1; ZPB
• Vector: PCMV6-Neo
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_021186 edited
  ATGTGGCTGCTGCGGTGCGTTTTGCTGTGTGTTTCATTATCTCTTGCTGTGAGTGGCCAG
  CATAAGCCTGAGGCACCAGATTATTCCAGTGTGCTCCACTGTGGGCCGTGGAGCTTCCAG
  TTTGCTGTAAACCTCAACCAGGAGGCAACGTCTCCTCCTGTACTAATAGCTTGGGACAAC
  CAAGGGCTGCTGCACGAGCTGCAGAATGACTCCGACTGTGGCACCTGGATAAGAAAAGGT
  CCAGGCAGCTCCGTGGTGTTGGAGGCAACCTATAGCAGCTGCTATGTCACTGAGTGGGAC
  TCCCACTACATCATGCCAGTTGGAGTTGAAGGAGCAGGCGCGGCTGAACACAAGGTGGTT
  ACAGAGAGGAAGCTGCTCAAGTGTCCTATGGATCTTCTAGCCCGAGATGCTCCAGATACT
  GACTGGTGTGACTCCATCCCAGCACGGGACAGACTGCCATGTGCACCTTCACCCATCTCT
  CGAGGAGACTGTGAAGGGCTAGGCTGTTGTTATAGCTCTGAAGAGGTGAATTCCTGCTAC
  TATGGAAACACTGTGACCTTGCATTGTACCCGAGAGGGCCATTTCTCTATTGCTGTGTCT
  CGGAACGTGACCTCGCCACCACTGCTCTTGGATTCTGTGCGCTTGGCCCTTAGGAATGAC
  AGTGCGTGTAACCCTGTGATGGCAACACAAGCTTTTGTTCTGTTCCAGTTTCCATTTACT
  TCCTGTGGCACCACAAGACAGATCACTGGAGACCGAGCAGTATATGAAAATGAACTGGTG
  GCAACTAGGGATGTGAAAAATGGGAGCCGTGGCTCTGTCACTCGTGACAGCATCTTCAGG
  CTCCATGTCAGCTGCAGCTACTCAGTAAGTAGCAACTCTCTCCCAATCAATGTCCAGGTT
  TTCACTCTCCCACCACCCTTTCCTGAGACCCAGCCTGGACCCCTCACTCTGGAACTTCAG
  ATTGCCAAAGATAAAAACTATGGCTCTTACTACGGTGTTGGTGACTACCCAGTGGTGAAG
  TTGCTTCGGGATCCCATTTACGTGGAGGTCTCCATCCTTCACAGAACAGACCCCTACCTG
  GGGCTGCTCCTACAACAGTGTTGGGCAACACCCAGCACTGACCCCCTGAGTCAGCCACAG
  TGGCCCATCCTGGTAAAGGGCTGCCCCTACATTGGAGACAACTATCAGACCCAGCTGATC
  CCTGTCCAGAAAGCCTTGGATCTTCCATTTCCCTCTCACCACCAGCGCTTCAGCATCTTC
  ACCTTCAGCTTTGTGAACCCTACAGTGGAGAAACAGGCCCTCAGGGGACCGGTGCATCTG
  CACTGCAGCGTGTCAGTCTGCCAGCCTGCTGAGACACCATCCTGTGTGGTGACCTGTCCT
  GATCTCAGTCGAAGAAGAAATTTTGACAACAGTTCTCAGAACACTACTGCTAGTGTTTCT
  AGCAAAGGCCCCATGATTCTACTCCAAGCCACTAAGGACCCTCCAGAAAAGCTCCGTGTT
  CCTGTAGACTCGAAAGTTCTGTGGGTGGCAGGCCTTTCTGGGACCTTAATCCTTGGAGCC
  TTGTTAGTATCCTACTTGGCTGTCAAGAAACAGAAGAGTTGCCCAGACCAAATGTGTCAA
  TAA
  
• Restriction Sites: Please inquire
• ACCN: NM_021186
• ORF Size: 1623 bp
• Insert Size: 1600
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_021186.2, NP_067009.1
• RefSeq Size: 1635
• RefSeq ORF: 1623
• Locus ID: 57829
• Protein Families: Secreted Protein, Transmembrane
• Gene Summary: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]